Clinical trial · Interventional
Evaluation of Continuous Positive Airway Pressure for Tumor Motion Management in Radiotherapy
Evaluation of CPAP (Continuous Positive Airway Pressure) in the Planning of Radiation Treatments for Lung, Upper Abdomen and Left Breast Cancers
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a clinical study on patients to compare the effects of CPAP on lung volume diaphragm motion, heart position and tumor motion compared to free breathing. Only patients with significant tumor motion of greater than 1 cm amplitude or unfavorable chest wall geometry (heart close to chest wall) identified on standard imaging and simulation will be candidates for the study. Patients will be re- simulated and planned for radiation treatments with CPAP. The radiation plans generated with and without CPAP will be compared to evaluate the impact of CPAP on tumor motion and dose delivered to adjacent critical structures such as the heart and lung.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Abdominal Tumors | — | UNRESOLVED | — |
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
| "Continuous Positive Airway Pressure" | — | UNRESOLVED | — |
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
| Tumor Motion | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Continuous positive airway pressure (CPAP) | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- EXPERIMENTAL
- label
- Lung tumors
- description
- Patients with \> 1 cm tumor motion simulated using 4DCT with and without CPAP
- interventionNames
- Device: Continuous positive airway pressure (CPAP)
- type
- EXPERIMENTAL
- label
- Left sided Breast cancer
- description
- Patients with heart abutting chest wall will be simulated using 4DCT with and without CPAP
- interventionNames
- Device: Continuous positive airway pressure (CPAP)
- type
- EXPERIMENTAL
- label
- Abdominal tumors
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Lung tumors and nodules with tumor motion greater than 1 cm on standard imaging * Left sided breast tumors with unfavorable anatomy, viz heart abutting chest wall * Upper abdominal tumors: Liver and Pancreas with tumor motion greater than 1 cm. (n=10) Exclusion Criteria: * Under 18 years old * Inability to sign informed consent * Pregnancy, * Mental Illness, * Not legally competent
References
Publications (0)
Data not yet available