Clinical trial · Interventional
The Effects of Gabapentin Premedication on Neurosurgery
The Effects of Gabapentin Premedication on Postoperative Pain,Nausea,Vomiting and Sedation in Patients Undergoing Neurosurgery
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The study is to observe the effects of gabapentin premedication on postoperative pain,vomiting and nausea in patients undergoing neurosurgery. 100 neurosurgical patients are randomized into groups gabapentin(GG) or placebo(GP). Patients are given gabapentin or placebo orally the night before operation day and 2hours before surgery,respectively.The investigators hypothesized that lower incidence of postoperative pain,vomiting and nausea be observed in GG than GP.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cerebral Tumor | Cerebral Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| gabapentin | Drug | — | UNRESOLVED |
| vitamin capsules | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- PLACEBO_COMPARATOR
- label
- vitamin capsules
- description
- vitamin capsules orally at the night before operation and 2 hours before surgery,respectively
- interventionNames
- Drug: vitamin capsules
- type
- EXPERIMENTAL
- label
- gabapentin
- description
- gabapentin 600mg orally at the night before operation and 2 hours before surgery,respectively
- interventionNames
- Drug: gabapentin
Primary outcomes (1)
- measure
- Premedication gabapentin can decrease pain in early postoperative period
- timeFrame
- 24 hour after extubation
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * 18-65 years old, ASA physical status I or II, BMI\<30 * Scheduled for elective craniotomy * Cooperative and given informed consent in person Exclusion Criteria: * History of mental or psychiatric disorders * Pregnant or lactating female * History of systemic malignant tumor or diabetes * Previously treated with this protocol or participated in another experimental study within previous 30 days * Suspected history of allergic reaction or intolerance to gabapentin or other anesthetic agents in this study * History of alcohol abuse and/or drug abuse within previous one year
References
Publications (0)
Data not yet available