Clinical trial · Interventional
Study of Tumor Metabolism by Isotopic Tagging in Patients With High-grade Glioma (CARBONOMIC)
NCT02305056CI-TRIAL-00032832CARBONOMICterminatedPhase 1ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of the study is to follow tumoral proteins metabolism by in vivo no radioactive isotopic tagging (carbon 13 and nitrogen 15).
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| High-grade Glioma | High-Grade Glioma, NOS | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| C13 N15 Valine | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- C13 N15 Valine
- description
- Intervention C13 N15 Valine
- interventionNames
- Drug: C13 N15 Valine
Primary outcomes (1)
- measure
- Mass spectrometry measurement of C13 labelled proteins
- timeFrame
- during 30 hours
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 90 Years
Show eligibility criteria text
Inclusion Criteria: * more or equal than 18 years old * patient affiliated to social security or similarly regime * informed consent form signed * High-grade Glioma tumor suspicion * Resective surgery indication * Hematological assessment : * neutrophils \> 1500/mm3 * Platelet \> 150 000 * blood Creatinin normal * alkaline Phosphatases and transaminases no more than two times normal * Bilirubin \< 1.5 times normal Exclusion Criteria: * Pregnant women and lactating mothers * Ward of court or under guardianship * Adult unable to express their consent * Person deprived of freedom by judicial or administrative decision * Person hospitalized without their consent * Person under legal protection * Precedent complete macroscopic tumor resective surgery * No valid inclusion criteria * Intratumoral hemorrhage MRI detected * Treatment anticoagulant or antisludge treatments * Active Infections and non controled or medical affection or psychiatric intercurrent non treated * Evolutive cerebral oedema without corticoid response * Non controled Epilepsy without antiepileptics response * Karnofsky score \< 40% * Weight \> 100 kg * No possibility of resective surgery
References
Publications (0)
Data not yet available
No reference posted for this study.