Clinical trial · Interventional
Hypoglossal Acupuncture for Dysgeusia in Patients Undergoing Chemotherapy
Hypoglossal Acupuncture for Dysgeusia in Gynecologic Cancer Patients Undergoing Chemotherapy: A Randomized Controlled Trial
NCT02304913CI-TRIAL-00108111OralAcurecruitingN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This randomized controlled trial aims to investigate hypoglossal acupuncture in comparison to sham acupuncture and standard medical treatment (dietary recommendations) in the treatment of dysgeusia in cancer patients undergoing chemotherapy.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Acupuncture | — | UNRESOLVED | — |
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
| Chemotherapy | — | UNRESOLVED | — |
| Dysgeusia | — | UNRESOLVED | — |
| Taste Disorders | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Dietary recommendations | Behavioral | — | UNRESOLVED |
| Hypoglossal acupuncture | Other | — | UNRESOLVED |
| Sham acupuncture | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- EXPERIMENTAL
- label
- Hypoglossal acupuncture
- description
- Single treatment of hypoglossal needle acupuncture during the chemotherapy administration: Treated points will be Jinjin (Golden Liquid/EX-HN12) left beside the lingual frenulum and Yuye (Jade Fluid/EX-HN13) right beside the lingual frenulum. Both points are treated in quick succession with immediate removal of the needle.
- interventionNames
- Other: Hypoglossal acupuncture
- type
- SHAM_COMPARATOR
- label
- Sham acupuncture
- description
- Single treatment of hypoglossal sham acupuncture uring the chemotherapy administration: Treated points will be 1 to 1.5 cun (a cun is defined as the width of the patient's thumb at the knuckle) beside the verum acupuncture points Jinjin and Yuye using the dull side of the needle.
- interventionNames
- Other: Sham acupuncture
- type
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Initial treatment with platinum-containing or taxane-based CTX (regardless of the the length of the CTX cycle) * Senological, gynecological or internistic tumors * Phantogeusia (on average ≥4 NRS) * Willingness to participate in the study and written informed consent Exclusion Criteria: * Severe stomatitis * Dysgeusia before the CTX based on neurological diseases, diabetes, or the ingestion of drugs with taste disorders as side effects * Leucopenia/neutropenia * Intake of anticoagulants * Smoking * Severe physical or mental comorbidity (due to which the patient is unable to participate in the study) * Participation in other CAM treatments within the integrative oncology care * Participation in other studies on the effectiveness of interventions for oral complications
References
Publications (1)
- DERIVEDHaller H, Wang T, Lauche R, Choi KE, Voiss P, Felber S, Cramer H, Ataseven B, Kummel S, Paul A, Dobos G. Hypoglossal acupuncture for acute chemotherapy-induced dysgeusia in patients with breast cancer: study protocol of a randomized, sham-controlled trial. Trials. 2019 Jul 4;20(1):398. doi: 10.1186/s13063-019-3525-y. PMID 31272494