Clinical trial · Interventional
Effects of Exercise on Cognitive Function in Glioma Patients
A Pilot Randomized Controlled Trial on the Feasibility and Efficacy of an Exercise Intervention to Improve Cognitive Functioning in Patients With Glioma
NCT02303938CI-TRIAL-00018746completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The objective of this pilot randomized controlled trial (RCT) is to assess the feasibility and to determine the effect size of an exercise program in improving objective cognitive functioning.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Anaplastic Glioma of Brain | — | UNRESOLVED | — |
| Low Grade Glioma of Brain | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| physical exercise | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- physical exercise
- description
- Patients will exercise three times per week for 6 months home-based exercise intervention. Session duration will vary between 20 minutes and 45 minutes.
- interventionNames
- Behavioral: physical exercise
- type
- NO_INTERVENTION
- label
- Active control group
- description
- Patients in the active control group will be advised to walk regularly based on brochures from 30minutenbewegen.nl
Primary outcomes (1)
- measure
- cognitive function as measured by neuropsychological tests
- timeFrame
- 6 months after the initial assessment
- description
- neuropsychological test battery will be administered to patients at baseline and immediately after the intervention at 6 months
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * Grade II and III gliomas * age \< 50 years * Karnofsky score \> or equal 80 * clinically stable for a minimum of 6 months prior to study entry * no recent anti-tumor treatment * interested in undergoing a physical exercise program * mild to moderate neuropsychological impairment based on normative comparison of objective test performance * relative VO2peak that leaves room for further improvement of cardiorespiratory fitness. Exclusion Criteria: * patients with serious orthopedic conditions or motor deficits * patients with serious cardiovascular, cardiopulmonary and neurological conditions (or risks) * patients judged to have psychiatric (including alcohol and drug abuse) * patients with severe cognitive problems * patients who report to engage in vigorous exercise (≥7 METs) for more than 20 minutes on at least 3 days per week on a regular basis will be excluded For assessment purposes, study participants will need to have basic fluency in the Dutch language.
References
Publications (0)
Data not yet available
No reference posted for this study.