Clinical trial · Interventional
CO2 Laser and Open Surgery for T1N0 Glottic SCC With Anterior Commissure Involved
Multicenter, Prospective, Randomized and Controlled Clinical Study 0f CO2 Laser and Open Surgery for T1N0 Glottic Squamous Cell Carcinoma With Anterior Commissure Involved
NCT02303457CI-TRIAL-00020692unknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Open surgery and CO2 laser surgery are both established treatment modalities for T1N0 glottic carcinoma. It is controversial for T1N0 glottic carcinoma with anterior commissure involved.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Squamous Cell Carcinoma of Glottis | Glottic Squamous Cell Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| CO2 Laser surgery | Procedure | — | UNRESOLVED |
| Open Surgery | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- CO2 laser surgery
- description
- CO2 Laser surgery for T1N0 Glottic Squamous Cell Carcinoma With Anterior Commissure Involved. All patients, under general anesthesia, underwent endoscopic excision of the lesion using a carbon dioxide (CO2) laser (Sharplan 100) coupled with a microscope (Zeiss) set to an output power of between 5 and 12 W in superpulse mode. The lesion's resection was accomplished in a radical fashion, with a free margin of 2 mm. For lesions which involved the anterior commissure, the excision plane always uncovered the cartilage.
- interventionNames
- Procedure: CO2 Laser surgery
- type
- OTHER
- label
- Open surgery
- description
- Open Surgery for T1N0 Glottic Squamous Cell Carcinoma With Anterior Commissure Involved. open surgery :Frontolateral Vertical Partial Laryngectomy or laryngofissure with cordectomy was accomplished in a radical fashion, with a free margin of 2 mm.
- interventionNames
- Procedure: Open Surgery
Primary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: * T1N0 SCC of glottic carcinoma with anterior commissure involve * No nodal metastasis and distant metastasis * All patients must have CT/MR and electronic laryngoscope test before surgery and after surgery * Expected lifetime\>1 year * Patients and families agreed to participate in the test and sign the informed consent * Without cognitive impairment. Exclusion Criteria: * With severe cardiac insufficiency Liver and kidney function is not complete systemic infection patients * Patients with pregnancy and lactation * Have surgery contraindications
References
Publications (0)
Data not yet available
No reference posted for this study.