Clinical trial · Observational
Breast Cancer Survivorship & Work-Related Cognitive Limitation
The Relationship Between Biopsychosocial Functioning and Work-Related Cognitive Limitation Among Employed Breast Cancer Survivors: Case Control Study.
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The proposed study seeks to evaluate the relationship between biopsychosocial functioning and work-related cognitive limitation among employed breast cancer survivors in a cross-sectional study with healthy control group. Specifically, this study will assess work-related cognitive limitation in association with depression, anxiety, pain, fatigue, sleep disturbance, and cognitive deficit of employed women with and without history of breast cancer. The primary purpose of this study is to assess the impact of objective cognitive functioning as a better predictor of cognitive shortcomings at work place in comparison to a self-report cognitive measure. The secondary purpose is to assess work related cognitive limitation in breast cancer survivors in comparison to their counterparts (employed women without history of cancer diagnosis). The third purpose is to explore how sociodemographic variables such as marital status, education, age, race, and ethnicity relates to perceived cognitive limitation at work among breast cancer survivors. Additionally, the study will examine the effects of medical variables as covariates on these relationships. Subsequently, the study will examine the level of mindful attention and awareness as a possible mediator between the psychological, somatic and cognitive distress and the work-related cognitive limitation. In this observational study, the control group is added as a mean to compare differences between groups and that no variables is being manipulated in this study. This precludes this research from being a quasi- or a true experimental design.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (2)
- label
- Breast cancer survivor Group
- description
- Breast Cancer Survivor Group includes: women between the ages of 18 to 69 who have received a stage I-III diagnosis of breast cancer in the past and completed primary treatment and finished with treatment for at least 6 months; currently employed working part-time or full-time at the time of assessment. Participants working between 1 to 34 hours a week will be considered part-time employees.
- label
- Control Group
- description
- Control Group includes: women between the ages of 18 to 60 who are healthy with no diagnosis of cancer, currently employed working part-time or full-time at the time of assessment. Participants working between 1 to 34 hours a week will be considered part-time employees.
Primary outcomes (1)
- measure
- Objective Cognitive Performance
- timeFrame
- 1 year
- description
- Cognitive Performance in this study is constructed as a measure of executive functioning, working memory, attention and concentration. It is a construct that is being studied to assess the relation between psychosocial variables and work-related cognitive functioning among employed breast cancer survivors using the following measure: Lumosity Brain Performance Test (BPT) \[Objective Cognitive Measure: which includes: Trail-making test, Memory Span assessments, Grammatical reasoning, and Stop signal task\].
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 69 Years
Show eligibility criteria text
Inclusion Criteria for breast cancer survivor group: * Female * Between the age of 18 to 69 years old * Working part-time or full-time at the time of the assessment * English-speaking * Have Internet and computer access * Have completed primary treatment and finished with treatment for at last 6 months (hormonal blockade therapy is permitted) * Have received a stage I-III diagnosis of cancer Inclusion Criteria for control group: * Female * Between the age of 18 to 69 years old * Working part-time or full-time at the time of the assessment * English-speaking * Have Internet and computer access * Have no cancer diagnosis Exclusion Criteria: * Diagnosis of dementia, history of brain injury and adult attention deficit hyperactivity (ADHD), epilepsy, current drug or alcohol abuse
References
Publications (39)
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- BACKGROUNDBender CM, Sereika SM, Berga SL, Vogel VG, Brufsky AM, Paraska KK, Ryan CM. Cognitive impairment associated with adjuvant therapy in breast cancer. Psychooncology. 2006 May;15(5):422-30. doi: 10.1002/pon.964. PMID 16097037
- BACKGROUNDBiegler KA, Chaoul MA, Cohen L. Cancer, cognitive impairment, and meditation. Acta Oncol. 2009;48(1):18-26. doi: 10.1080/02841860802415535. PMID 19031161
- BACKGROUNDBiglia N, Bounous VE, Malabaila A, Palmisano D, Torta DM, D'Alonzo M, Sismondi P, Torta R. Objective and self-reported cognitive dysfunction in breast cancer women treated with chemotherapy: a prospective study. Eur J Cancer Care (Engl). 2012 Jul;21(4):485-92. doi: 10.1111/j.1365-2354.2011.01320.x. Epub 2011 Dec 28. PMID 22211832
- BACKGROUNDBlinder VS, Murphy MM, Vahdat LT, Gold HT, de Melo-Martin I, Hayes MK, Scheff RJ, Chuang E, Moore A, Mazumdar M. Employment after a breast cancer diagnosis: a qualitative study of ethnically diverse urban women. J Community Health. 2012 Aug;37(4):763-72. doi: 10.1007/s10900-011-9509-9. PMID 22109386
- BACKGROUNDBoykoff N, Moieni M, Subramanian SK. Confronting chemobrain: an in-depth look at survivors' reports of impact on work, social networks, and health care response. J Cancer Surviv. 2009 Dec;3(4):223-32. doi: 10.1007/s11764-009-0098-x. Epub 2009 Sep 16. PMID 19760150