Clinical trial · Interventional
Non-invasive Focal Therapy for Osteoid Osteoma
Treatment of Osteoid Osteoma With MR Guided High Intensity Focused Ultrasound
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Non-invasive treatment of Osteoid osteoma using MRI guided high-intensity focused ultrasound. This study is designed as an intention-to-treat using a totally non-invasive approach for pain reduction, quality of life improvement and long-term bone restoration. Procedure is performed in a single session using limited amount of acoustic energy to target the osteoid nidus. Treatment will be performed under anesthesia (peripheral or general according to age and lesion position).
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Osteoma, Osteoid | Osteoid Osteoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| MR guided High Intensity focused ultrasound | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- OTHER
- label
- Osteoid Osteoma
- description
- MR guided High Intensity focused ultrasound
- interventionNames
- Device: MR guided High Intensity focused ultrasound
Primary outcomes (2)
- measure
- Safety - Adverse Events (serious and otherwise)
- timeFrame
- 1 year
- description
- to assess complications
- measure
- Efficacy (Symptoms reduction)
- timeFrame
- 4 years
- description
- Symptoms reduction
Secondary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 3 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * clinical and imaging diagnosis of osteoid osteoma * painful non-vertebral location Exclusion Criteria: * general contraindication to MRI * vertebral location of the lesion * claustrophobia and prior surgery or RFA are not an absolute exclusion criterion
References
Publications (1)
- DERIVEDNapoli A, Bazzocchi A, Scipione R, Anzidei M, Saba L, Ghanouni P, Cozzi DA, Catalano C. Noninvasive Therapy for Osteoid Osteoma: A Prospective Developmental Study with MR Imaging-guided High-Intensity Focused Ultrasound. Radiology. 2017 Oct;285(1):186-196. doi: 10.1148/radiol.2017162680. Epub 2017 Jun 7. PMID 28590796