Clinical trial · Observational
The Impact of Laparoscopic Versus Open Surgeries on the Incidence of Postoperative Deep Vein Thrombosis in Patients With Gastrointestinal Malignancy ---A Cohort Study
NCT02297269CI-TRIAL-00016134unknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Deep vein thrombosis (DVT) is a common complication of surgery, which could result in pulmonary embolism (PE). PE is a serious and potentially life-threatening syndrome. The purpose of this study is to investigate the impact of laparoscopic versus open surgeries on the incidence of postoperative DVT in patients with gastrointestinal malignancy
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Deep Vein Thrombosis | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| laparoscopic surgery | Device | — | UNRESOLVED |
| open surgery | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- group laparoscopic surgery
- description
- Participants undergo laparoscopic gastrointestinal malignancy surgery will be included in this group. The pressure of pneumoperitoneum maintain in 10-12mmHg.
- interventionNames
- Device: laparoscopic surgery
- label
- group open surgery
- description
- Participants undergo open gastrointestinal malignancy surgery will be included in this group.
- interventionNames
- Device: open surgery
Primary outcomes (1)
- measure
- the incidence of DVT
- timeFrame
- within 7 days postoperatively
- description
- DVT will be measured by color Doppler ultrasonography
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: 1. clinical diagnosed with gastrointestinal malignancy 2. aged from 18 to 75 years old 3. woman or man 4. classification of American Society of Anesthesiologists is I to III Exclusion Criteria: 1. patients with rectal tumor need to resect anus 2. tumor distant metastasis 3. patients with palliative surgery 4. diagnosed with DVT pre-operation 5. body mass index ≤18 or ≥30 6. coagulation dysfunction 7. cerebral hemorrhage history pre-operation 8. hepatorenal dysfunction 9. being pregnant 10. mental disorder 11. patients with peritonitis or uncontrolled general infection
References
Publications (21)
- BACKGROUNDMichota F. Venous thromboembolism: epidemiology, characteristics, and consequences. Clin Cornerstone. 2005;7(4):8-15. doi: 10.1016/s1098-3597(05)80098-5. PMID 16758647
- BACKGROUNDNguyen NT, Owings JT, Gosselin R, Pevec WC, Lee SJ, Goldman C, Wolfe BM. Systemic coagulation and fibrinolysis after laparoscopic and open gastric bypass. Arch Surg. 2001 Aug;136(8):909-16. doi: 10.1001/archsurg.136.8.909. PMID 11485526
- BACKGROUNDNguyen NT, Wolfe BM. The physiologic effects of pneumoperitoneum in the morbidly obese. Ann Surg. 2005 Feb;241(2):219-26. doi: 10.1097/01.sla.0000151791.93571.70. PMID 15650630
- BACKGROUNDPatel MI, Hardman DT, Nicholls D, Fisher CM, Appleberg M. The incidence of deep venous thrombosis after laparoscopic cholecystectomy. Med J Aust. 1996 Jun 3;164(11):652-4, 656. PMID 8657026
- BACKGROUNDLord RV, Ling JJ, Hugh TB, Coleman MJ, Doust BD, Nivison-Smith I. Incidence of deep vein thrombosis after laparoscopic vs minilaparotomy cholecystectomy. Arch Surg. 1998 Sep;133(9):967-73. doi: 10.1001/archsurg.133.9.967. PMID 9749849
- BACKGROUNDBrown JA, Garlitz C, Gomella LG, McGinnis DE, Diamond SM, Strup SE. Perioperative morbidity of laparoscopic radical prostatectomy compared with open radical retropubic prostatectomy. Urol Oncol. 2004 Mar-Apr;22(2):102-6. doi: 10.1016/S1078-1439(03)00101-7. PMID 15082005
- BACKGROUNDO'Shea RT, Cook JR, Seman EI. Total laparoscopic hysterectomy: a new option for removal of the large myomatous uterus. Aust N Z J Obstet Gynaecol. 2002 Aug;42(3):282-4. doi: 10.1111/j.0004-8666.2002.00282.x. PMID 12230064
- BACKGROUNDGeerts WH, Heit JA, Clagett GP, Pineo GF, Colwell CW, Anderson FA Jr, Wheeler HB. Prevention of venous thromboembolism. Chest. 2001 Jan;119(1 Suppl):132S-175S. doi: 10.1378/chest.119.1_suppl.132s. No abstract available.