Clinical trial · Observational
Fernald Community Cohort -18 Year Observational Study
Fernald Community Cohort - 18 Year Observational Study with Bio Banked Blood and Urine Samples
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The Fernald Community Cohort consists of the 9782 persons who were enrolled in the Fernald Medical Monitoring Program (FMMP) (1990-2008). The initial comprehensive examination conducted as part of the Fernald Medical Monitoring Program (FMMP) began in the autumn of 1990. The FMMP provided 9,782 initial examinations and 42,775 re-examinations. An extensive computerized database and biospecimen repository was created to provide research resources for future studies. All questionnaire, examination and diagnostic procedure data collected from the FMMP were \[coded by certified medical record coders,\] double entered with verification into a SAS database on site of the examinations. Cryo-preserved blood and urine samples were collected at enrollment and at various intervals throughout follow-up. At the first examination three 1-ml aliquots of whole blood, plasma, serum, urine and urine with buffer were obtained from each participant (15 aliquots per person) for future analyses. Additional whole blood and serum was obtained in 1996-1997 and 2006-2008. Specimens have been stored in -80 degree freezers; over 160,000 biospecimens are in the archive. Since 1994, the FCC has had an established procedure for sharing data and biospecimens with qualified researchers. Both the policy and application forms can be found at www.eh.uc.edu/fmmp/research.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
| Cardiovascular Disease | — | UNRESOLVED | — |
| Diabetes | — | UNRESOLVED | — |
| Renal Failure | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Incident cancer during the period of cohort follow-up
- timeFrame
- From enrollment to most recent encounter, average of 12 years, range of 1 day to 18 years
- description
- Using information from the medical examinations, medical history, assigned ICD codes and diagnosis verification with pathology reports, cancer outcomes are noted in the database with diagnosis date and method of diagnosis verification.
Secondary outcomes (1)
- measure
- Incident renal disease during the period of cohort follow-up
- timeFrame
- From enrollment to most recent encounter, average of 12 years, range of 1 day to 18 years
- description
- Using information from the medical examinations, medical history, laboratory tests of blood serum and urine, and assigned ICD codes, persons with renal disease are noted in the database with diagnosis date and method of diagnosis verification.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 8 Years
Show eligibility criteria text
Inclusion Criteria: Lived or worked within five miles of the Feed Material Processing Center (FMPC) for 2 consecutive years between January 1, 1952 and December 18, 1984. The Fernald Community Cohort (N=9782) includes 5294 female and 4489 male participants; 99.5% are Caucasian. The FMMP has conducted 42,775 medical examinations through the end of 2008. \- Exclusion Criteria: Worked at the Feeds Material Processing Center (FMPC) Employed by the US Department of Energy or National Lead of Ohio, Inc. (Plant Contractor) \-
References
Publications (30)
- BACKGROUNDFitzpatrick S, Nolan RD, Hallam JS, Pinney SM. Ecological grief in the Fernald Community Cohort: A pilot study. PLOS Ment Health. 2024 Jun 18;1(1):e0000049. doi: 10.1371/journal.pmen.0000049. eCollection 2024. PMID 41661708
- BACKGROUND4. Burcham S, Saul D., Nolan RD., Pinney SM. (2024). Exposure Experiences of Area Residents Near a Chronic Environmental Contamination Site. Ohio Journal of Public Health, 6(1), 1-9. https://doi.org/10.18061/ojph.v6i1.9701
- BACKGROUNDRubinstein J, Pinney SM, Xie C, Wang HS. Association of same-day urinary phenol levels and cardiac electrical alterations: analysis of the Fernald Community Cohort. Environ Health. 2024 Sep 19;23(1):76. doi: 10.1186/s12940-024-01114-x. PMID 39300535
- BACKGROUNDLi Y, Xiao X, Li J, Han Y, Cheng C, Fernandes GF, Slewitzke SE, Rosenberg SM, Zhu M, Byun J, Bosse Y, McKay JD, Albanes D, Lam S, Tardon A, Chen C, Bojesen SE, Landi MT, Johansson M, Risch A, Bickeboller H, Wichmann HE, Christiani DC, Rennert G, Arnold SM, Goodman GE, Field JK, Davies MPA, Shete S, Marchand LL, Liu G, Hung RJ, Andrew AS, Kiemeney LA, Sun R, Zienolddiny S, Grankvist K, Johansson M, Caporaso NE, Cox A, Hong YC, Lazarus P, Schabath MB, Aldrich MC, Schwartz AG, Gorlov I, Purrington KS, Yang P, Liu Y, Bailey-Wilson JE, Pinney SM, Mandal D, Willey JC, Gaba C, Brennan P, Xia J, Shen H, Amos CI. Lung Cancer in Ever- and Never-Smokers: Findings from Multi-Population GWAS Studies. Cancer Epidemiol Biomarkers Prev. 2024 Mar 1;33(3):389-399. doi: 10.1158/1055-9965.EPI-23-0613. PMID 38180474
- BACKGROUNDWones R, Pinney SM, Buckholz JM, Deck-Tebbe C, Freyberg R, Pesce A. Medical monitoring: a beneficial remedy for residents living near an environmental hazard site. J Occup Environ Med. 2009 Dec;51(12):1374-83. doi: 10.1097/JOM.0b013e3181c558f1. PMID 19952785
- BACKGROUNDBlomkalns AL, Gavrila D, Thomas M, Neltner BS, Blanco VM, Benjamin SB, McCormick ML, Stoll LL, Denning GM, Collins SP, Qin Z, Daugherty A, Cassis LA, Thompson RW, Weiss RM, Lindower PD, Pinney SM, Chatterjee T, Weintraub NL. CD14 directs adventitial macrophage precursor recruitment: role in early abdominal aortic aneurysm formation. J Am Heart Assoc. 2013 Mar 8;2(2):e000065. doi: 10.1161/JAHA.112.000065.