Omega 3 Fatty Acids and ERPR(-)HER2(+/-) Breast Cancer Prevention

Inclusion Criteria:

* Prior diagnosis of Stage 0 to III breast cancer that is estrogen receptor negative, progesterone receptor negative with completion of definitive surgery, radiation therapy and/or chemotherapy.
* Completion of chemotherapy or trastuzumab for \> six months and of radiation therapy for \> 2 months, as applicable and 5 years or less from completion of standard therapy.
* Greater than 1 year from pregnancy, lactation.
* Mammogram within the eight months prior to study enrollment that is not suspicious for breast cancer (ACR Class I-III).

Exclusion Criteria:

* Other current malignancy or metastatic malignancy of any kind.
* Ongoing chemotherapy, radiation therapy, or other cancer-related treatment.
* Subjects on Coumadin or other anticoagulants.
* Subjects with breast implants.
* Subjects who have had radiation to both breasts or who have undergone bilateral mastectomies.
* Barriers to fine needle aspiration sampling of breast adipose tissue and/or parenchymal breast tissue, including breast implants, history of radiation to both breasts, bilateral mastectomies, and/or insufficient breast adipose/parenchymal tissue for adequate fine needle aspiration (FNA) sampling.
* Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, hypertension, or psychiatric illness/social situation that would limit compliance with study requirements.
* Chronic use of omega 3 fatty acid concentrates or capsules within the 3 months prior to entry on the study or any other supplements that might interact with omega 3 fatty acid supplements.
* Pregnant or nursing women.
* Known sensitivity or allergy to fish.
* Subjects on a standing regimen of full dose aspirin (greater than 325 mg/day), NSAIDs (nonsteriodal anti inflammatory drug) or NSAID-containing products.