Clinical trial · Observational
Computed Tomography (CT) Coronary Angiogram Evaluation in Cancer Patients Having CT Thorax, Abdomen and Pelvis
Feasibility of Computed Tomography (CT) Coronary Angiogram Evaluation in Cancer Patients Having CT Thorax, Abdomen and Pelvis (CT TAP)
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Currently patients with certain cancer usually have routine follow up (Computed Tomography of Thorax, Abdomen and Pelvis) CT TAP scans to see response to treatment or relapse. The study proposal allows the evaluation of the coronary arteries by modifying the current CT TAP technique without significant additional procedures, intravenous contrast or radiation - i.e. an opportunistic Computed Tomography Coronary Angiogram (CTCA) without any penalty. The question is does performing Computed Tomography (CT) of the thorax in such a way confer important additional information about cardiac risk? At the same time the investigators need to ensure that doing scan as per CTCA protocol produces equivalent image quality to evaluate other structures in the chest. A recent small retrospective study has using a similar technique suggests that it may in fact improve image quality due to less cardiac related motion artefact.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Coronary Stenosis | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| CT TAP Scan | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- CT TAP scan
- description
- Suitable patients will be identified after consultant radiologists have approved a request for cancer routine CT TAP scan.
- interventionNames
- Radiation: CT TAP Scan
Primary outcomes (3)
- measure
- Objective Image quality analysis
- timeFrame
- 20 minutes
- description
- Calculating image noise as measured by standard deviation (SD) in a region of interest.
- measure
- Objective Image quality analysis
- timeFrame
- 20 minutes
- description
- Calculating contrast-to-noise ratio (CNR)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 40 Years
Show eligibility criteria text
Inclusion Criteria: * Patients having routine follow up cancer CT TAP scan * Age more than or equal to 40 years of age at the time of scan. * Able to provide informed written consent * Able to hold their breath for at least 10 seconds * Has regular heart rate * Able to follow verbal commands for breath holding and remain still for the duration of scanning * Able to lie supine for the entirety of the scan Exclusion Criteria: * Patient unable to give informed consent. * Patients unable to lie supine * Patient not able to breath hold for at least 10 seconds. * Patients not having regular heart rate. Patient with atrial fibrillation or \>2 atrial or ventricular premature beats on a preoperative 12 lead ECG (suboptimal image quality results from irregular heart rhythms) * Patient having eGFR \<30, to avoid risk of contrast nephrotoxicity in patients potentially at risk) or chronic renal failure on dialysis * Patient has known contrast reaction. * Patient is pregnant. * Patients BMI\>35 * Unavailability of research slot to accommodate for the urgency of the scan requested.
References
Publications (0)
Data not yet available