Clinical trial · Interventional
Response of VEGF and AT-II to HCG in PCOS
The Higher Response of Vascular Endothelial Growth Factor and Angiotensin-II to Human Chorionic Gonadotropin in Women With Polycystic Ovary Syndrome
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This research is to investigate the response of vascular active factors, vascular endothelial growth factor (VEGF) and angiotensin-Ⅱ (AT-Ⅱ) to ovary stimulation during 24h in patients with polycystic ovary syndrome (PCOS).Controled prospective clinical study involved 60 women undergoing in vitro fertilization. Fifty-two patients with PCOS and 8 control cases were stimulated with human chorionic gonadotropin (HCG) during the early follicular phase of the menstrual cycle (4st to 7th days of the cycle).The blood was sampled before the injection (0 hour) and at the 3, 6, 12, 18 and 24 hours points after the stimulation. VEGF, AT-Ⅱ were measured by radioimmunoassay.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Polycystic Ovary Syndrome | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| HCG | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- type
- EXPERIMENTAL
- label
- Group 1
- description
- typical PCOS
- interventionNames
- Drug: HCG
- type
- EXPERIMENTAL
- label
- Group 2
- description
- PCOS without PCO
- interventionNames
- Drug: HCG
- type
- EXPERIMENTAL
- label
- Group 3
- description
- PCOS without HA
- interventionNames
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 21 Years
- Maximum age
- 35 Years
Show eligibility criteria text
Inclusion Criteria: * A total of 60 women were recruited and divided into four groups by Rotterdam criteria according to three typical characters: 1. biochemical characteristics of hyperandrogenism (HA) 2. chronic anovulation 3. polycystic ovary morphology (PCO). Exclusion Criteria: * All women were matched for age (\<35 yr). * All subjects were screened, and no other endocrine disturbances (thyroid, adrenal) or medical illnesses were found. * All the patients did not have any hormonal preparation during the 3 months preceding the study.
References
Publications (1)
- DERIVEDQu J, Che Y, Xu P, Xia Y, Wu X, Wang Y. The Higher Response of Vascular Endothelial Growth Factor and Angiotensin-II to Human Chorionic Gonadotropin in Women with Polycystic Ovary Syndrome. Int J Fertil Steril. 2015 Jan-Mar;8(4):373-8. doi: 10.22074/ijfs.2015.4176. Epub 2015 Feb 7. PMID 25780518