Clinical trial · Interventional
Interest of Indocyanine Green in Neoplastic Prostatic Tissue
Interest of Indocyanine Green in the Neoplastic Prostatic Tissue Characterization and the Peroperative Surgical Margins Detection During a Radical Prostatectomy.
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Scientific coordinator left the hospital
Summary
Brief summary (as posted)
Prostate cancer, with more than 70,000 new cases and 8900 deaths a year in France, is a major public health problem. Until 28% of patients treated with surgery will present a positive surgical margin resulting in an incomplete clearance of the tumoral process and exposing so the patient at a local, systemic recurrence and increased morbidity. An increasing number of international publications have shown (ICG) was interesting for the detection of the sentinel lymph node, in the surgery of tumors of type hepatocarcinoma and liver metastases from colorectal diseases, but also in the surgery of the kidney, bladder or breast. ICG has affinity for tumor and tissues around the tumor related to micro-vascular histology for a localized and specific deposit (EPR effect). The detection of ICG 's deposits is now possible with to the use of a device which allow to visualize the infra-red fluorescence (NIR; Near Infra-Red) for objects larger than 0.15 mm. Thanks to this feature, the location of residual tumor tissue when performing a radical prostatectomy could be made much easier.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Prostatic Neoplasms | Prostate Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| indocyanine green infusion | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- patient with Indocyanine green infusion
- description
- Infusion of Indocyanine Green 0,25 mg/Kg 24h before prostatic surgery
- interventionNames
- Drug: indocyanine green infusion
Primary outcomes (1)
- measure
- Sensitivity of indocyanine green
- timeFrame
- 24h after indocyanine green infusion
- description
- Sensitivity (true positive) of the fluorescence due to indocyanine green to detect neoplasm tissue in prostatic biopsy compared to histological analysis
Secondary outcomes (1)
- measure
- Specificity of indocyanine green
- timeFrame
- 24h after indocyanine green infusion
Eligibility
Eligibility (as posted)
- Sex
- Male
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients with prostatic cancer proved by biopsy and needing total prostatectomy with or without curettage. * Patient affiliated to a social security scheme * Patient has given its informed consent Exclusion Criteria: * contra-indication to surgery * non confirmed adenocarcinoma diagnostic * antecedent of prostatic cancer treatment * antecedent of pelvic surgery
References
Publications (0)
Data not yet available