Clinical trial · Observational
The Influence of Glycaemia and Insulinemia on Vasomotor Endothelial Function After Myocardial Infarction
Influence of Glycaemia and Insulinemia on Vasomotor Endothelial Function After Ischemia/Reperfusion Lesion on Patients in Acute Phase of ST Segment Elevation Myocardial Infarction (STEMI)
NCT02250989CI-TRIAL-00015712INGLIVEFunknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The objective of this study is to investigative the influence of different levels of glycaemia or insulinemia in vascular endothelium in ischemia/reperfusion lesion after myocardial infarction
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Myocardial Infarction | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (3)
- label
- Hyperinsulinemia/Euglycaemia
- description
- In this group study, a condition of Hyperinsulinemia/Euglycaemia will be held trough clamp study, during witch FMD will be measured before and after ischemia/reperfusion injury.
- label
- Hyperinsulinemia/Hyperglycemia
- description
- In this group study, a condition of Hyperinsulinemia/Hyperglycemia will be held trough clamp study, during witch FMD will be measured before and after ischemia/reperfusion injury.
- label
- Hypoinsulinemia/Hyperglycemia group
- description
- In this group study, a condition of Hypoinsulinemia/Hyperglycemia will be held trough clamp study, during witch FMD will be measured before and after ischemia/reperfusion injury.
Primary outcomes (1)
- measure
- Change in endothelial function after ischemia/reperfusion injury
- timeFrame
- Between 144 and 168 h after Myocardial Infarction
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 40 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: * less than 12 hours from the onset of symptoms of STEMI, * reperfusion therapy performed less than 6 hours of symptom onset. Exclusion Criteria: * patients that after 24 hours did not show markers of myocardial necrosis * diabetes or use of oral antidiabetics * admission with glycosylated hemoglobin ≥ 6.5% * patients with creatinine clearance \<50 ml / min, * patients with BMI ≥ 40 kg / m2, * premenopausal women, * patients that used nitrate or vasoactive drugs (norepinephrine, dobutamine, nitroglycerin or nitroprussiate in 48h prior to the examination of endothelial function * cardiac dysfunction in acute MI with or without repercussion clinic, diagnosed by ejection fraction less than 50% left ventricle. * FMD values above or below 2 standard deviations or more from the average of these tests
References
Publications (0)
Data not yet available
No reference posted for this study.