Efficacy of CryoBalloon Focal Ablation System on Human Esophageal Barrett's Epithelium

Criteria Inclusion Criteria

* Patients with known Barrett's esophagus, with an indication for ablation therapy during which the cryoablation may be performed.
* Patient is 18 to 80 years of age at the time of consent (inclusive).
* Patient has provided written Informed Consent (IC) using an Informed Consent Form (ICF) that has been approved by the Institution's reviewing IRB/EC.
* Patient is willing and able to comply with all Clinical Investigation Plan (CIP) requirements.
* Patient is deemed operable per standard institutional criteria.
* BE lesion length \<6cm excluding visible BE islands, and Prague Classification C ≥ 0 / M ≥ 0.
* One of the following: Flat LGD, Flat HGD, Residual BE after EMR for visible lesions (containing any degree of dysplasia or low-risk early adenocarcinoma (i.e.: not poorly differentiated, negative vertical (deep) resection margins, absence of (lympho)vascular invasion), Residual BE after a single circumferential RFA (performed for indications listed above: i-iii)
* BE lesion within the treatment zone should be flat

Exclusion Criteria

* Esophageal stenosis preventing advancement of a therapeutic endoscope within 4 cm of treatment zone.
* Patient has a known history of unresolved drug or alcohol dependency that would limit ability to comprehend or follow instructions related to informed consent, post treatment instructions or follow-up guidelines.
* Patient refuses or is unable to provide written informed consent.
* Patients that are pregnant.
* Patient with endoscopically active inflammation in the treatment zone.
* Endoscopically visible abnormalities such as masses or nodules requiring endoscopic resection.