Clinical trial · Interventional
Exercise and QUality Diet After Leukemia: The EQUAL Study
NCT02244411CI-TRIAL-00119239completedN/AResults postedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The EQUAL study has been designed for adult survivors of childhood acute lymphoblastic leukemia (ALL) who are overweight or obese. The purpose of this study is to see if diet and exercise can help people lose weight and improve other health problems. This two year study will compare two methods of informing participants about ways to lose weight.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Adult Survivors of Childhood Leukemia | — | UNRESOLVED | — |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| fasting blood draw, measurement of height, weight and waist circumference, and blood pressure | Other | — | UNRESOLVED |
| individual diet & physical activity counselor and website through Healthways at Hopkins | Behavioral | — | UNRESOLVED |
| questionnaires | Behavioral | — | UNRESOLVED |
| self directed weight loss | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Intervention group
- description
- Participants will be assigned an individual diet \& physical activity counselor through Healthways at Hopkins. This counselor will stay with the participant for the 24 months. The primary communication with the counselor will be via website \& email. Participants will be encouraged to consume a low-calorie, low-salt diet with 7-12 daily servings of fruits, vegetables \& low-fat dairy products. Calorie goals are based upon weight at study entry \& whether or not the weight loss goal has been met. Participants will gradually build to ≥ 180 minutes of moderate to vigorous physical activity per week, using the activity of their own choosing \& gradually adding bouts of ≥ 10 minutes in length. Monitoring \& Counselor Contacts: the first 3 months, the participants are encouraged to log into the web hub on a daily basis to record weight, food intake, \& physical activity. Participants who decline or drop out of the intervention program will remain on-study doing home visits \& questionnaires.
- interventionNames
- Behavioral: individual diet & physical activity counselor and website through Healthways at Hopkins
- Behavioral: questionnaires
- Other: fasting blood draw, measurement of height, weight and waist circumference, and blood pressure
- type
- ACTIVE_COMPARATOR
- label
- control group
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: Eligibility will be confirmed via the CCSS-based medical record and by a series of questions on the EQUAL website, prior to consent. * Participation in the CCSS cohort * Diagnosed with acute lymphoblastic leukemia \< 18 years of age * Cancer free at time of study enrollment * Current age ≥ 18 years * A body mass index (BMI) ≥ 25 kg/m2 (overweight or obese), as determined by self-reported height and weight on the most recent CCSS questionnaire * Internet access and a personal email account * Able to read and comprehend informed consent Exclusion Criteria: * Prior history of congestive heart failure, coronary artery disease, myocardial infarction, stroke, or unstable angina; * Medical condition for which weight loss might be contraindicated or which would cause weight loss, such as pregnancy, anorexia or bulimia; * Use of prescription weight loss medication within the previous 6 months * History of total body irradiation (TBI)
References
Publications (1)
- DERIVEDFriedman DN, Chou JF, Clark JM, Moskowitz CS, Ford JS, Armstrong GT, Mubdi NZ, McDonald A, Nathan PC, Sklar CA, Ramanathan LV, Robison LL, Oeffinger KC, Tonorezos ES. Exercise and QUality Diet after Leukemia: A Randomized Weight Loss Trial among Adult Survivors of Childhood Leukemia in the Childhood Cancer Survivor Study. Cancer Epidemiol Biomarkers Prev. 2024 Sep 3;33(9):1158-1166. doi: 10.1158/1055-9965.EPI-23-1601. PMID 38652494