Clinical trial · Interventional
Diffusion-Weighted Magnetic Resonance Imaging
Response Assessment for External Beam Radiation Therapy in Spinal Metastasis of Hepatocellular Carcinoma (HCC): Usefulness of Diffusion-Weighted Magnetic Resonance (MR) Imaging as A Functional Imaging
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Recently, diffusion-weighted (DW) MR imaging has widened its application on various oncologic applications. Especially, it is expected the DW MRI could provide valuable information about early response evaluation after treatment using rapid apparent diffusion coefficient (ADC) value change. It has demonstrated potential usefulness in response evaluation in the liver tumors after treatments such as transarterial chemoembolization (TACE) and radiation therapy (RT). Furthermore, it is a functional imaging technique that does not require a contrast agent, it can be safely used in patients with renal insufficiency or other medical contraindications for contrast agents. The optimal assessment of early response of RT could provide one of the most important information to prescribe patient and cancer specific RT dose. It might be also important in palliative RT of HCC bone metastasis which is related with painful aggressive mass formation. This study is performed to evaluate the usefulness of DW MRI in early response evaluation after RT for HCC bone metastasis.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hepatocellular Carcinoma | Hepatocellular Carcinoma | ONTOLOGY_EXACT | 0.98 |
| Spine Metastasis | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| External beam radiation therapy | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- EBRT
- interventionNames
- Radiation: External beam radiation therapy
Primary outcomes (1)
- measure
- oral morphine equivalent doseresponse criteria
- timeFrame
- 3 months after RT completion
- description
- Degree of pain will be assessed via Visual Analog Scale for Pain (VAS).
Secondary outcomes (4)
- measure
- Modified Response Evaluation Criteria in Solid Tumor
- timeFrame
- 3 months after RT completion
- measure
- Time to local tumor progression
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
Show eligibility criteria text
Inclusion Criteria: * Hepatocellular carcinoma * Spine metastasis * Eastern Cooperative Oncology Group (ECOG) performance status 0 to 3 * 20 or older age * informed consent * consent to birth control during 6 months after treatment Exclusion Criteria: * less than 12 weeks of expected survival * indication of emergency operation * uncontrolled ascites or encephalopathy * previous RT field lesion (within in 1 month)
References
Publications (0)
Data not yet available