Clinical trial · Interventional
The Effect of Norepinephrine and Dopamine on Radial Forearm Free Flap Tissue Oxygen Pressure and Microdialysate Metabolite Measurements
NCT02241083CI-TRIAL-00015620completedPhase 4ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Vasopressors may be needed after head and neck microvascular reconstructions to maintain sufficient mean arterial pressure. This is crucial for the flap survival. The study hypothesis is that norepinephrine and dopamine used as vasopressors do not affect flap tissue oxygen level and microdialysate metabolites.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Head and Neck Cancer | Malignant Head and Neck Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Dopamine | Drug | — | UNRESOLVED |
| no medication | Other | — | UNRESOLVED |
| Norepinephrine | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- ACTIVE_COMPARATOR
- label
- dopamine group
- description
- vasopressor dosage individually titred according to the mean arterial pressure
- interventionNames
- Drug: Dopamine
- type
- ACTIVE_COMPARATOR
- label
- norepinephrine group
- description
- vasopressor dosage individually titred according to the mean arterial pressure
- interventionNames
- Drug: Norepinephrine
- type
- ACTIVE_COMPARATOR
- label
- control group
- description
- no medication
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * head and neck cancer patients having tumor ablation surgery and reconstruction with microvascular radial forearm flap Exclusion Criteria: * Patients having contraindications for the operation. * Patient refusal to participate in the study
References
Publications (0)
Data not yet available
No reference posted for this study.