Clinical trial · Interventional
Visual Inspection With Acetic Acid Compared to Lugol's Iodine in HIV-infected Women
Safety and Validity Evaluation for Cervical Cancer Screening and Treatment Techniques Among HIV-infected Women
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The clinical trial is part of a larger study to evaluate the safety and efficacy of screening techniques for cervical cancer among HIV-infected women. The investigators randomized women to undergo screening with Visual Inspection with Acetic Acid (VIA) or Visual Inspection with Lugol's Iodine (VILI), along with a colposcopy. All outcome and treatment decisions were based on the colposcopy exam done at the study visit. The investigators then compared outcomes between the two groups to assess the test characteristics of both VIA and VILI.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cervical Cancer | Malignant Cervical Neoplasm | CURATED_EXACT | 0.92 |
| Cervical Intraepithelial Neoplasia | Cervical Intraepithelial Neoplasia | ONTOLOGY_EXACT | 0.98 |
| HIV | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Visual Inspection with Acetic Acid | Procedure | — | UNRESOLVED |
| Visual Inspection with Lugol's Iodine | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Visual Inspection with Lugol's Iodine
- description
- Participants underwent colposcopic exam, followed by Visual Inspection with Lugol's Iodine (VILI) by a second, blinded clinician (the order of exams was reversed to eliminate potential interference with exam results due to iodine staining). Biopsy was done after the VILI.
- interventionNames
- Procedure: Visual Inspection with Lugol's Iodine
- type
- ACTIVE_COMPARATOR
- label
- Visual Inspection with Acetic Acid
- description
- Participants underwent Visual Inspection with Acetic Acid followed by colposcopy by a second clinician who was blinded to the screening test result.
- interventionNames
- Procedure: Visual Inspection with Acetic Acid
Primary outcomes (1)
- measure
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 23 Years
- Maximum age
- 59 Years
Show eligibility criteria text
Inclusion Criteria: * 23-59 * Intact cervix/uterus * no evidence of infection * ability to provide informed consent Exclusion Criteria: * pregnant
References
Publications (1)
- DERIVEDHuchko MJ, Sneden J, Zakaras JM, Smith-McCune K, Sawaya G, Maloba M, Bukusi EA, Cohen CR. A randomized trial comparing the diagnostic accuracy of visual inspection with acetic acid to Visual Inspection with Lugol's Iodine for cervical cancer screening in HIV-infected women. PLoS One. 2015 Apr 7;10(4):e0118568. doi: 10.1371/journal.pone.0118568. eCollection 2015. PMID 25849627