Clinical trial · Interventional
Preoperative Oral Dexamethasone to Improve Recovery After Surgery
The Use of Preoperative Oral Dexamethasone to Improve Quality of Recovery After Breast Surgery
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Randomized controlled trial of pre-operative oral dexamethasone vs placebo for the improvement of quality of recovery from surgery. The study population is limited to breast surgery patients. The investigators will also look at the effect of our intervention on post operative nausea and vomiting. Patients will be recruited before the date of their surgery and will complete the Quality of Recovery-40 (QOR-40) questionnaire before their surgery and at 24 hours post op. They will also complete a Clinically significant nausea and vomiting score upon discharge from the post anesthesia recovery room, repeated at 24 hours post op.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Gelatin capsule | Other | — | UNRESOLVED |
| Ondansetron | Drug | — | UNRESOLVED |
| Oral dexamethasone | Drug | Dexamethasone | ALIAS |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Oral Dexamethasone
- description
- Oral dexamethasone- two 4mg tabs and one 2mg tab contained within a gelatin capsule Administered a single time, 2 hours pre-induction Ondansetron 6mg IV will be administered at skin closure
- interventionNames
- Drug: Oral dexamethasone
- Drug: Ondansetron
- Other: Gelatin capsule
- type
- PLACEBO_COMPARATOR
- label
- Gelatin pill
- description
- Gelatin capsule contained within second gelatin capsule. Administered a single time, 2 hours pre-induction Ondansetron 6mg IV will be administered at skin closure
- interventionNames
- Drug: Ondansetron
- Other: Gelatin capsule
Primary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Adults (18 to 80 years of age) undergoing general anesthesia for elective breast surgery (lumpectomy or mastectomy) and providing informed consent. * American Society of Anesthesia (ASA) class I, II, \& III patients Exclusion Criteria: * ASA class IV and V patients * Pregnancy * Diabetes * History of allergy to any study medications * Use of steroids or anti emetics within 1 month of surgery * Chronic pain requiring opioid treatment * History of alcohol or drug abuse (including smoking tobacco) * Severe renal impairment (i.e. serum creatinine more than 160 umol/L) * Poor English comprehension or psychiatric/central nervous system disturbance that would preclude completion of the QoR-40 questionnaire
References
Publications (0)
Data not yet available