Clinical trial · Interventional
Open-label, Dose-finding Study to Determine Antibody Response to G17DT Treatment in Patients With Gastric Cancer.
An Open-label, Dose-finding, Schedule-changing, Multi-center Study to Determine the Antibody Response to G17DT Treatment of Patients With Gastric Cancer.
NCT02233712CI-TRIAL-00015556GC3completedPhase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
An open label, dose-finding, schedule-changing, sequential, multiple dose, multi-center study in patients with Stage I-III gastric cancer. The first group of patients received a starting dose of 250 µg at weeks 0, 1, and 3. Thereafter, allocation to treatment with 100 µg or 500 µg was based on antibody response and dose tolerability.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Gastric Cancer | Malignant Gastric Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| G17DT | Biological | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- type
- EXPERIMENTAL
- label
- Group 1
- description
- G17DT; 250 µg dose administered at 0, 1, and 3 weeks.
- interventionNames
- Biological: G17DT
- type
- EXPERIMENTAL
- label
- Group 2
- description
- G17DT; 100 µg dose administered at 0, 1, and 3 weeks.
- interventionNames
- Biological: G17DT
- type
- EXPERIMENTAL
- label
- Group 3
- description
- G17DT; 500 µg dose administered at 0, 1, and 3 weeks.
- interventionNames
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Histologically confirmed UICC Stage I, II or III gastric adenocarcinoma. Must have had a macroscopically curative resection for gastric cancer with absence of metastatic disease at the time of entry to the trial * Male or female and over 18 years of age * Must have a life expectancy of at least three months * World Health Organization Performance Status of 0 to 1 * Given written conformed consent Exclusion Criteria: * Gastric surgery within four weeks of baseline (week 0) or gastric surgery anticipated in the period of the study * History of other malignant disease within the previous five years, except non-melanomatous skin cancer or in situ carcinoma of the uterine cervix * Previous use within the last four weeks, concomitant use or anticipated use in the period of the study, of any anti-cancer therapies * Concomitant use of immunosuppressants, including systemic (i.e. oral or injected) corticosteroids * Females who pregnant, planning to become pregnant or lactating * Taking part in another study involving an investigational or licensed drug or device in the three months preceding enrollment or during this study * Previously received G17DT treatment * Haemoglobin (Hb) \< 10.0 g/dL White blood cell count (WBC) \< 4.0 x 10\^9/L Platelets \< 100 x 10\^9/L
References
Publications (0)
Data not yet available
No reference posted for this study.