Clinical trial · Interventional
PET CT With HX4 in Cervix Cancer
Non Invasive Imaging of [18F]HX4 With Positron-Emission-Tomography (PET) in Cervix Cancer.
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): patients did not want to participate
Summary
Brief summary (as posted)
The aim of this study is: 1. to determine if tumor hypoxia can be accurately visualised with \[18F\]HX4 PET imaging in cervix cancer, 2. to correlate the \[18F\]HX4 PET images with blood and tissue markers, 3. to investigate the quality and optimal timing of \[18F\]HX4 PET images, 4. to compare \[18F\]HX4 PET uptake with \[18F\]FDG PET uptake before and after treatment and 5. analyze correlation with responses
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cervix Cancer | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| injection with [18F] HX4 and PET imaging | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- [18F] HX4 PET imaging
- description
- injection with \[18F\] HX4 and PET imaging at baseline and after 20 Gy radiotherapy
- interventionNames
- Other: injection with [18F] HX4 and PET imaging
Primary outcomes (1)
- measure
- Visualisation of tumor hypoxia with [18F] HX4 PET imaging
- timeFrame
- 2 year
- description
- Visualisation of tumor hypoxia with \[18F\] HX4 PET imaging
Secondary outcomes (8)
- measure
- Observation of spatial and temporal stability of [18F] HX4 PET images
- timeFrame
- 2 year
- description
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion criteria * Histologically confirmed cervix carcinoma (squamous cell carcinoma, adenocarcinoma or adenosquamous carcinoma) * tumor stages FIGO IB - IVA * WHO performance status 0 to 2 * Scheduled for primary curative radiotherapy (either or not combined with chemotherapy or hyperthermia) * No previous surgery to the Cervix * No previous radiation to the Cervix * The patient is willing and capable to comply with study procedures * 18 years or older * Written informed consent before patient registration Exclusion criteria * Recent (\< 3 months) myocardial infarction * Uncontrolled infectious disease * Pregnant or breast feeding and/or not willing to take adequate contraceptive measures during the study
References
Publications (0)
Data not yet available