Clinical trial · Interventional
Randomized, Controlled Trial of Endoscopic Ultrasound-Guided Bilateral Celiac Plexus Neurolysis vs Celiac Ganglia Neurolysis to Control Pain in Inoperable Pancreatic Cancer Patients With Inadequate Pain Control by Pain Killer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Pancreatic cancer related pain can be difficult to control, even with high doses of narcotics, whose adverse effects may further impair quality of life. So EUS-CPN(endoscopic ultrasound guided celiac plexus neurolysis) is well established as an effective technique for controlling pain and reducing narcotic requirements in patients with pancreatic cancer. Recently, celiac ganglia can be visualized and accessed by endoscopic ultrasound. So it allows for direct injection into individual celiac ganglia to perform celiac ganglia neurolysis. This more precise delivery of therapeutic drug will offers the potential for enhanced efficacy and safety. To evaluate this hypothesis, this randomized controlled trial aimed to compare the efficacy and safety of EUS-CGN(Endoscopic ultrasound guided celiac ganglia neurolysis) vs. Bilateral EUS-CPN(Endoscopic ultrasound guided celiac plexus neurolysis) in providing relief from pancreas cancer-related pain.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pancreatic Neoplasms | Pancreatic Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| EUS-CGN | Procedure | — | UNRESOLVED |
| EUS-CPN | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- EUS-CPN group
- description
- Group that be performed by Endoscopic ultrasound guided bilateral celiac plexus neurolysis
- interventionNames
- Procedure: EUS-CPN
- type
- EXPERIMENTAL
- label
- EUS-CGN group
- description
- Group that be performed by Endoscopic ultrasound guided celiac ganglia neurolysis
- interventionNames
- Procedure: EUS-CGN
Primary outcomes (1)
- measure
- percentage of participants with 50% decrease or less than 3 points in Pain Visual Analogue Scale (VAS)
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 19 Years
Show eligibility criteria text
Inclusion Criteria: 1. At least 19 years old age (above 70 years old age, need the consent of the legal representative) 2. Inoperable pancreatic cancer patients 3. Pancreatic cancer patients with inadequate pain control by pain killer (VAS score 4 points or more) 4. Patient who agree to participate in this study Exclusion Criteria: 1. Abnormal clotting (international normalized ratio ≥1.5) 2. Reduced platelet count (≤50000/μL) 3. Use of anticoagulation agents 4. Presence of gastric and/or esophageal varices 5. Anatomical deformity due to past surgery
References
Publications (0)
Data not yet available