PANGEA-IMBBP: Personalized Antibodies for Gastro-Esophageal Adenocarcinoma - A 1st Pilot Metastatic Trial of Biologics Beyond Progression

Inclusion Criteria:

1. Histologically confirmed metastatic gastric or esophagogastric junction (type I,II,III Siewert) adenocarcinoma
2. Newly-diagnosed chemo-naïve or recurrent after curative-intent surgery

   * \>6 months after completion of adjuvant therapy (including chemotherapy and/or radiotherapy)
   * No prior treatment with any targeted agent
   * Patients who have started first line mFOLFOX6 therapy (+/-trastuzumab for HER2 amplified tumors) may be considered for trial participation if they have received no more than 4 doses of therapy at the time of consent and screening.
3. Measurable metastatic disease by RECIST criteria,

   * Must be amenable to ultrasound or CT-guided biopsy of one metastatic lesion
   * Peritoneal disease as the sole site of occult metastasis or presenting as malignant ascites is acceptable if a cell block of tumor cells can be obtained showing \>20% viable tumor cells.
4. ECOG PS 0,1
5. Age \> 18 years
6. Patients must have normal organ and marrow function as defined below:

   * granulocytes \>1,2500/mcL
   * platelets \>100,000/mcL
   * total bilirubin \< 1.5 x ULN, \<1.8 x ULN with liver metastases
   * AST(SGOT)/ALT(SGPT) \<2.5 X ULN without liver metastases; \<5 X ULN with liver metastases
   * creatinine within normal institutional limits (\<1.5) OR
   * creatinine clearance \>50 mL/min/1.73m2, (for creatinine level above normal)
   * INR: \< 1.5 (patients on warfarin need to be converted to LMWH during study participation to be eligible)
7. Consent to baseline metastatic and progressive disease biopsy (of metastatic/progressing lesion) for enabling biomarker assessment and treatment assignment (at each time point - baseline, PD1, PD2, PD3) as well as for correlative studies.

   • Consent to baseline and serial blood draws for plasma/serum/whole blood banking for correlative studies
8. Ability to understand and the willingness to sign a written informed consent document and consent to the serial nature of the proposed PANGEA treatment with first, second and third line therapy as tolerated.
9. Ability to comply with requirements of the protocol, as assessed by the investigator by the patient signing the consent form.
10. If history of exposure to anthracyclines during perioperative treatment, the following cumulative doses of anthracyclines must be less than:

    Epirubicin \< 720 mg/m2 Doxorubicin or liposomal doxorubicin \< 360 mg/m2 Mitoxantrone \> 120 mg/m2 and idarubicin \> 90 mg/m2 If more than one anthracycline has been used, then the cumulative dose must not exceed the equivalent of 360 mg/m2 of doxorubicin.
11. Cardiac Ejection Fraction \>50% (for HER2+ patients) as assessed by echocardiogram, MUGA scan, or cardiac MRI
12. Willingness to use effective and reliable methods of contraception (For appropriate methods of contraception considered acceptable see Appendix B).

Both men and women and members of all races and ethnic groups are eligible for this trial.

Exclusion Criteria:

1. No CVA within 6 months, no recent MI within 6 months
2. No currently active second malignancy
3. No uncontrolled intercurrent illness or infection
4. No peripheral edema \> grade 2 at baseline.
5. No peripheral neuropathy \> grade 2 at baseline.
6. No diarrhea \> grade 2 at baseline.