Clinical trial · Observational
Identification the Cause of Cerebral Infarction in Patients With Cancer
NCT02212496CI-TRIAL-00039327completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Although there has been increasing interest in the association between cancer and cerebrovascular disease, the underlying pathophysiology of stroke in cancer patients is still not fully understood. The aim of this study is to investigate the stroke mechanisms in patients with cancer-associated stroke.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Active Cancer | — | UNRESOLVED | — |
| Cryptogenic Embolic Stroke | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (2)
- label
- Cancer-associated stroke
- description
- Cryptogenic embolic stroke with active cancer
- label
- Cryptogenic embolic stroke
- description
- Cryptogenic embolic stroke without active cancer
Primary outcomes (1)
- measure
- Prevalence of deep vein thrombosis and microembolic signal in cancer related stroke patients
- timeFrame
- Within one week after enrollment
- description
- Venous thromboembolism was investigated via Doppler sonography and/or computed tomography pulmonary angiography combined with venous phase CT angiography of the lower extremities. Microembolic signal was detected via transcranial Doppler sonography on symptomatic cerebral circulation
Secondary outcomes (2)
- measure
- Impact of intravascular thrombosis on infarct volume
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Subjects with acute ischemic stroke who presented within 7 days from symptom onset * Subjects who had embolic infarction outside the perforator territory revealed by diffusion-weighted imaging * Subjects with undetermined cause of stroke despite of initial evaluation including electrocardiogram and brain imaging upon admission * Subjects who performed brain magnetic resonance image (MRI) and MR angiography (MRA), cardiac work-ups (12-lead electrocardiography, transthoracic and/or transesophageal echocardiography with injection of agitated saline (or agitated saline transcranial Doppler monitoring), and 24-hour Holter and/or telemonitoring) * Subjects with informed consent Exclusion Criteria: * Subjects with single subcortical infarction * Subjects with primary brain tumor * Inability to perform comprehensive studies * Refusal or withdrawal of the consent
References
Publications (1)
- DERIVEDHa J, Lee MJ, Kim SJ, Park BY, Park H, Cho S, Chung JW, Seo WK, Kim GM, Bang OY, Chung CS. Prevalence and Impact of Venous and Arterial Thromboembolism in Patients With Embolic Stroke of Undetermined Source With or Without Active Cancer. J Am Heart Assoc. 2019 Nov 5;8(21):e013215. doi: 10.1161/JAHA.119.013215. Epub 2019 Oct 23. PMID 31640456