Clinical trial · Interventional
Reproducibility and Repeatability of Multifunctional MRI Biomarkers of the Body
NCT02201797CI-TRIAL-00018366completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Advanced MRI (Magnetic Resonance Imaging) technique called DCE (Dynamic Contrast Enhanced) and DWI MRI can provide valuable information regarding tumor biology and response to treatment through various parameters. Validating stability of these parameters will further establish robustness and reliability of these promising biomarkers.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Metastatic Liver Cancer | Malignant Liver Neoplasm | CURATED_BROADER | 0.78 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| DCE MRI | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- DCE and DWI MRI
- description
- MRI SCAN 1 and MRI SCAN 2 must be completed no less than 2 calendar days (to ensure 24 hours for clearance of gadolinium) and no greater than 14 days apart, and both must be completed prior to new treatment initiation. The same MRI unit and configuration must be used for MRI SCAN 1 and MRI SCAN 2.
- interventionNames
- Other: DCE MRI
Primary outcomes (1)
- measure
- repeatability coefficient (RC)
- timeFrame
- one year
- description
- Repeatability coefficient of Ktrans, Kep, Ve, IAUGC60, and ADC value of the index tumor will be measured.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Diagnosis of metastatic liver cancer proven by pathology * At least one liver tumor should be \> 2cm in long diameter * Patients with viable tumor proven in the other imaging modalities Exclusion Criteria: * Severe claustrophobia * Presence of MRI-incompatible metallic objects or implanted medical devices in body * Renal failure, as determined by glomerular filtration rate (GFR) \< 30 mL/min/1.73 m2 * Weight greater than that allowable by the MRI table * Chemotherapy within 28 days prior to enrollment * Prior external radiation therapy to the liver, prior transarterial chemoembolization
References
Publications (0)
Data not yet available
No reference posted for this study.