Clinical trial · Interventional
Study of the Relationship Between Clinical and Paraclinical Markers During Situations of Cachexia and Pre-cachexia in Patients Over 70 Years With Colorectal Surgery
ANC2 Pilot Study Study of the Relationship Between Clinical and Paraclinical Markers During Situations of Cachexia and Pre-cachexia in Patients Over 70 Years With Colorectal Surgery
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Cachexia associated with cancer is a grave and most of the time irreversible common situation. It seems independent from the size of the tumor or from its metastatic character. The consequences for the management of the patient are major and exceed widely the frame of the nutrition. Undernutrition of patients with cancer is described by a decrease of the energy contributions and a loss of muscular and fat mass, leading to a progressive functional deficiency which can go to the cachectic state. Actually, clinical criteria are proposed allowing to characterize the state of pre-cachexia but it remain too indistinct to allow an early and efficient screening and set up effective measures of prevention of the cachexia, to avoid the loss of muscular tissue and the cast iron of the energy reserves. It is necessary to have clinical and biological markers with diagnostic aim and forecasts during the situations precedents the appearance of cachexia. The present study will allow calibrating a longitudinal study, which could confirm the value of measures made for the diagnosis of pre-cachexia.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Tumor | Colorectal Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (9)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Biopsy of adipose and muscular tissue | Procedure | — | UNRESOLVED |
| Blood sampling | Other | — | UNRESOLVED |
| Calorimetry | Other | — | UNRESOLVED |
| Evaluation of emotional status | Other | — | UNRESOLVED |
| Evaluation of functional status | Other | — | UNRESOLVED |
| Evaluation of muscular strength | Other | — | UNRESOLVED |
| Evaluation of nutritional status | Other | — | UNRESOLVED |
| Evaluation of physical performance | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Patients with colorectal surgery
- interventionNames
- Procedure: Biopsy of adipose and muscular tissue
- Other: Blood sampling
- Other: Calorimetry
- Other: Impedance measure
- Other: Evaluation of nutritional status
- Other: Evaluation of physical performance
- Other: Evaluation of muscular strength
- Other: Evaluation of emotional status
- Other: Evaluation of functional status
Primary outcomes (1)
- measure
- biological and radiological markers
- timeFrame
- During perioperative period (from date of consent until discharge from the hospital, up to 30 postoperative days)
- description
- Validated criteria of cachexia, pre-cachexia and sarcopenia are applied. Systematic preoperative measures (TNFα, leptin, ghrelin) and CT scanning of the abdomen/pelvis are performed for all patient enrolled.
Secondary outcomes (4)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: * Aged ≥ 70 years * Colorectal tumor resection with/without synchronous metastases Exclusion Criteria: * Emergency resection of colorectal tumor * Unresectable colorectal tumor with/without synchronous metastases
References
Publications (0)
Data not yet available