Clinical trial · Observational
Study of Cardiac MRI in Patients With Left-Sided Breast Cancer Receiving Radiation Therapy
Prospective Pilot Study of Early Markers of Radiation-Induced Cardiac Injury in Patients With Left-Sided Breast Cancer Receiving Photon or Proton Therapy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a pilot study to determine if there are changes in heart function following completion of radiation therapy for breast cancer as measured by cardiac magnetic resonance imaging (cardiac MRI) scans. Additional purposes of this study are to assess cardiac side effects from radiation treatment, evaluate cardiac MRI changes by radiation technique, and compare quality of life questionnaires.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Cardiac magnetic resonance (cardiac MRI) | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Cardiac magnetic resonance (cardiac MRI)
- description
- Participants will have a cardiac MRI at baseline and within 1 year after completion of radiation therapy.
- interventionNames
- Procedure: Cardiac magnetic resonance (cardiac MRI)
Primary outcomes (1)
- measure
- Proportion of participants with changes in cardiac function.
- timeFrame
- 1 year after completion of radiation therapy
- description
- A change in cardiac function may include shifts from baseline measures of LV mass, strain, ejection fraction, and late gadolinium enhancement.
Secondary outcomes (2)
- measure
- Proportion of patients with serious cardiac side effects.
- timeFrame
- 1 year after completion of radiation therapy
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Left-sided breast cancer stage I-III. * Indications for adjuvant regional nodal and breast or chest wall radiation therapy (RT). * Women and men are allowed. * Must be at least 18 years old at time of consent. Exclusion Criteria: * Pregnant and/or breastfeeding women or patients of child-producing potential not willing to use contraception while on study. * Prior history of cardiovascular disease per physician discretion. * Stage 0 and IV breast cancer. * Prior radiation therapy to chest. * Concurrent trastuzumab per physician discretion.
References
Publications (0)
Data not yet available