Clinical trial · Interventional
Acid Pocket: Position and Aspiration
Acid Pocket: Different Position and Chemical Content Between Healthy Volunteers and GERD Patients
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Gastroesophageal reflux disease (GERD) is a very common condition affecting up to 30% of adults. To date, therapy consists of powerful acid suppression with proton pump inhibitors (PPI). Nevertheless, only 60-70% of GERD patients report complete symptom relief with this therapy. As the mechanisms underlying symptom perception in PPI resistant patients are not fully understood, there is currently no adequate therapy available. It is becoming increasingly clear that reflux, especially in the postprandial period, occurs from a reservoir of acid floating on top of the meal: the so-called "acid pocket". In this study, we aim to investigate further the acid pocket by determining its exact position and chemical contents between healthy volunteers, GERD patient who respond well and bad to PPI therapy and GERD patients with barrett's esophagus.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Barrett Esophagus | — | UNRESOLVED | — |
| GERD - PPI Non-responders | — | UNRESOLVED | — |
| GERD - PPI Responders | — | UNRESOLVED | — |
| Healthy Volunteers | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| multi-pH-impedance manometry catheter | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (5)
- type
- OTHER
- label
- healthy volunteers
- description
- healthy volunteers (no gastric complains)
- interventionNames
- Device: multi-pH-impedance manometry catheter
- type
- OTHER
- label
- PPI responders
- description
- proven reflux, good symptom relief upon PPI therapy
- interventionNames
- Device: multi-pH-impedance manometry catheter
- type
- OTHER
- label
- PPI non-responders
- description
- proven reflux disease, poor symptom control (less then 50% symptom reduction) upon PPI therapy (2x40mg omeprazole)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * signed informed consent * older than 18 years * fit to criteria of 'study population' (HV, PPI responder, PPI non-responder, Barrett) Exclusion Criteria: * pregnancy
References
Publications (0)
Data not yet available