Clinical trial · Interventional
Pulsed Dye Laser in Treating Patients With Post Radiation Dysphonia
Pulsed Dye Laser for Treatment of Post Radiation Dysphonia
NCT02198131CI-TRIAL-00065968completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This pilot trial studies pulsed dye laser in treating patients with post radiation dysphonia. Dysphonia, or vocal cord scarring, can include trouble with the voice when trying to talk, such as hoarseness, change in voice pitch, and poor voice quality, and it commonly happens after radiation therapy for laryngeal cancer. Pulsed dye laser may improve post radiation dysphonia.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Oral Complications of Radiation Therapy | — | UNRESOLVED | — |
| Stage II Laryngeal Cancer | Malignant Laryngeal Neoplasm | CURATED_BROADER | 0.78 |
| Stage I Laryngeal Cancer | Malignant Laryngeal Neoplasm | CURATED_BROADER | 0.78 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| laser therapy | Procedure | — | UNRESOLVED |
| questionnaire administration | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Supportive Care (pulsed dye laser)
- description
- Patients undergo pulsed dye laser monthly for three months.
- interventionNames
- Procedure: laser therapy
- Other: questionnaire administration
Primary outcomes (7)
- measure
- Videostroboscopy rates
- timeFrame
- Up to 6 months post-treatment
- description
- Forced choice comparisons will be utilized in the pre and post treatment stroboscopy comparisons.
- measure
- Change in Voice Handicap Index (VHI)-10 score
- timeFrame
- Baseline to 6 months post-treatment
- description
- The VHI-10 form will be scored and then those numbers will be compared pre and post treatment for each individual.
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * Patients suffering from dysphonia after radiation therapy for glottic carcinoma will be included in the study * Patients will be included if their initial stage was T1 N0 M0 or T2 N0 M0 Exclusion Criteria: * Patients having previously undergone large surgical resections of the larynx or hypopharynx will be excluded * Patients fewer than 1 year out from completion of radiation therapy will be excluded * Patients with local disease recurrence would be excluded from the trial * Patients in whom the transnasal endoscope is poorly tolerated or patients in whom transnasal endoscopic laryngoscopy is contraindicated will be excluded
References
Publications (0)
Data not yet available
No reference posted for this study.