Clinical trial · Interventional
A Comprehensive Smoking Cessation Intervention Duration Radiation for Upper Aerodigestive Cancers
Efficacy and Impact of a Comprehensive Smoking Cessation Intervention During Radiation for Upper Aerodigestive Cancers
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Smoking is the greatest risk factor for upper aerodigestive cancers (thoracic or head and neck) and negatively impacts survival and other outcomes, but many patients have difficulty quitting after their diagnosis. Smoking cessation interventions for cancer patients thus far have had limited success. This is a pilot randomized controlled trial designed to determine if a new comprehensive, evidence-based smoking cessation intervention can improve quit rates for cancer patients who smoke.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Head and Neck Neoplasms | Head and Neck Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Radiation | — | UNRESOLVED | — |
| Thoracic Neoplasms | Thoracic Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Tobacco Use Disorder | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Comprehensive smoking cessation intervention | Other | — | UNRESOLVED |
| Enhanced usual care | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Comprehensive intervention
- description
- New evidence-based comprehensive smoking cessation intervention including several elements that have proven successful in non-cancer patients but not used for cancer patients before.
- interventionNames
- Other: Comprehensive smoking cessation intervention
- type
- ACTIVE_COMPARATOR
- label
- Enhanced usual care
- description
- Intervention consistent with the U.S. Department of Health and Human Services guidelines for tobacco treatment.
- interventionNames
- Behavioral: Enhanced usual care
Primary outcomes (1)
- measure
- Smoking cessation
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 105 Years
Show eligibility criteria text
Inclusion Criteria: * New diagnosis of head and neck or thoracic (including lung) cancer * Undergoing radiation at Johns Hopkins Radiation Oncology for 5 or more weeks * English-speaking and able to provide informed consent * Smoked any cigarettes in previous 14 days Exclusion Criteria: * Palliative radiation * Undergoing stereotactic radiosurgery * Pregnant or breastfeeding
References
Publications (1)
- DERIVEDHolliday R, Hong B, McColl E, Livingstone-Banks J, Preshaw PM. Interventions for tobacco cessation delivered by dental professionals. Cochrane Database Syst Rev. 2021 Feb 19;2(2):CD005084. doi: 10.1002/14651858.CD005084.pub4. PMID 33605440