Clinical trial · Observational
Usefulness of Serum Pepsinogen and Gastrin as the Predictive Biomarker of Atrophic Gastritis, Intestinal Metaplasia and Gastric Cancer in Korea
NCT02184910CI-TRIAL-00037659unknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
It is well-known that atrophic gastritis is a major risk factor for gastric cancer, which leads to variations in the serum levels of gastrin, pepsinogen (PG) I, and PGII. We want to assess the effects of age, sex, and Helicobacter pylori status on pepsinogen (PG) level for atrophic gastritis and whether gastric atrophy based on the PG test would be improved after H. pylori eradication.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Atrophic Gastritis | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| pepsinogen and gastrin | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- gastritis and pepsinogen
- interventionNames
- Drug: pepsinogen and gastrin
Primary outcomes (1)
- measure
- the change of pepsinogen level before and after H. pylori eradication
- timeFrame
- baseline and 6 months
- description
- to compare the change of the pepsinogen level before and after H. pylori eradication and evaluate the correlation between the pepsinogen level and the atrophic gastritis
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 19 Years
Show eligibility criteria text
Inclusion Criteria: 1. over 19 years 2. the patients who have gastrointestinal discomfort or get esophagogastroduodenoscopy (EGD) for health check up 3. the patients who got the procedure, endoscopic submucosal resection (ESD) for early gastric cancer Exclusion Criteria: 1. gastrectomy history 2. advanced gastric cancer (impossible to get the gastrectomy) 3. Helicobacter eradication history 4. the patients who have chronic disease 5. cancer patients except gastric cancer within 6 months 6. who cannot perform this study according to research's decision 7. who have bleeding tendency (ex. taking antiplatelet agent, low platelet count or abnormal coagulation time)
References
Publications (0)
Data not yet available
No reference posted for this study.