Clinical trial · Interventional
Effect of Magnesium Supplementation on Polycystic Ovary Syndrome
Effect of Magnesium Supplementation on Metabolic Profile and Sex Hormone Levels in Overweight Women With Polycystic Ovary Syndrome.
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a double-blind randomized clinical trial which will start at June 2014 and end on June 2015 in Isfahan city. Serum insulin level is considered as a key variable and the sample size calculated 70 persons (35 persons for control group and 35 persons for patient group). Patient group will receive magnesium supplement (250 milligram) and the other group will receive placebo which is similar to the magnesium tablets in color, odor and appearance both for 8 weeks. All subjects will complete 4 physical activity and 4 dietary records. Outcome measurements including sex hormone levels, metabolic and inflammatory profiles will be measured at the beginning and end of the study as well as anthropetric measurements.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Polycystic Ovary Syndrome | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Magnesium Oxide | Dietary Supplement | — | UNRESOLVED |
| Placebo | Dietary Supplement | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Magnesium Oxide
- description
- magnesium tablets, 250 milligram magnesium, 8 weeks, every day 1 tablet
- interventionNames
- Dietary Supplement: Magnesium Oxide
- type
- PLACEBO_COMPARATOR
- label
- Placebo
- description
- Placebo tablets, the same in color, odor and appearance with magnesium tablets, 8 weeks, one tablet every day
- interventionNames
- Dietary Supplement: Placebo
Primary outcomes (1)
- measure
- Serum insulin level
- timeFrame
- 8 Weeks
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 20 Years
- Maximum age
- 45 Years
Show eligibility criteria text
Inclusion Criteria: * Having PCOS according to the Rotterdam criteria, * Age between 20-45 years, * Lack of pregnancy and lactation, * Not having certain regime during last 3 months, * Non-smoking, * Not having diseases, including: diabetes, cardiovascular , hepatic, renal and thyroid, * Not taking supplements, * Being overweight (Kg / m 25 ≤ BMI) Exclusion Criteria: * Hormone Therapy, * Pregnancy and lactation during the study, * Severe weight loss (more than 2.5 kg per month) during the study
References
Publications (1)
- DERIVEDFarsinejad-Marj M, Azadbakht L, Mardanian F, Saneei P, Esmaillzadeh A. Clinical and Metabolic Responses to Magnesium Supplementation in Women with Polycystic Ovary Syndrome. Biol Trace Elem Res. 2020 Aug;196(2):349-358. doi: 10.1007/s12011-019-01923-z. Epub 2020 Jan 20. PMID 31960275