Clinical trial · Interventional
Anesthetic Agents and Acute Kidney Injury After Liver Resection Surgery
Effects of Different Inhalational Anesthetic Agents on the Incidence of Clinical and Subclinical Acute Kidney Injury After Liver Resection Surgery: a Pilot Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): I retired my post before enrollment
Summary
Brief summary (as posted)
* It has been shown that patients who undergo liver resection surgery are at high risk for postoperative acute kidney injury (AKI). * Sevoflurane may increase the risk for postoperative AKI because of production of compound-A. * Therefore, we have planned to investigate the effects of different anesthetic agents on postoperative renal function. * Patients undergoing liver resection surgery are randomized into 2 groups. * One of the groups receives sevoflurane and the other group receives desflurane. * Blood and urine specimen are sampled both pre- and postoperatively, and several biomarkers are compared between the groups.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cholangiocarcinoma | Cholangiocarcinoma | ONTOLOGY_EXACT | 0.98 |
| Gallbladder Neoplasms | Gallbladder Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Hepatocellular Carcinoma | Hepatocellular Carcinoma | ONTOLOGY_EXACT | 0.98 |
| Hepatoma | Hepatocellular Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Desflurane | Drug | — | UNRESOLVED |
| Sevoflurane | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Sevoflurane
- description
- Patients are randomized into 2 groups (Desflurane group and Sevoflurane group) depending on the anesthetic agents administered during anesthesia.
- interventionNames
- Drug: Sevoflurane
- type
- ACTIVE_COMPARATOR
- label
- Desflurane
- description
- Patients are randomized into 2 groups (Desflurane group and Sevoflurane group) depending on the anesthetic agents administered during anesthesia.
- interventionNames
- Drug: Desflurane
Primary outcomes (1)
- measure
- Postoperative acute kidney injury
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
Show eligibility criteria text
Inclusion Criteria: * Forty adult patients (20 patients in each group) who are planned to undergo liver resection surgery are included. Exclusion Criteria: * Patients who undergo less invasive resection surgery under thoracoscopy or laparoscopy are excluded. Patients with chronic kidney disease, or allergic to any anesthetic agents used in the study are also excluded.
References
Publications (0)
Data not yet available