Clinical trial · Interventional
Intestinal Microflora in Colorectal Cancer (CRC) After Chemotherapy
Effects of Gut Microflora on the Immune and Nutritional Status of CRC Patients After Chemotherapy
NCT02169388CI-TRIAL-00014928unknownPhase 1ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Probiotics modulate the gut microflora and immune status in CRC,which can reduce the side effects of chemotherapy such as diarrhea,infection,neutropenia etc.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
| Effects of Chemotherapy | — | UNRESOLVED | — |
| Gastrointestinal Neoplasms | Digestive System Neoplasm | ALIAS | 0.90 |
| Malnutrition | — | UNRESOLVED | — |
| Tumor Immunity | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| placebo（for probiotic） | Drug | — | UNRESOLVED |
| Probiotic | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Probiotic
- description
- Microbial composition using Probiotic，3 capsules / times, 2 times / day for 4 weeks
- interventionNames
- Drug: Probiotic
- type
- PLACEBO_COMPARATOR
- label
- placebo
- description
- Microbiota modulation using placebo，3 capsules / times, 2 times / day for 4 weeks
- interventionNames
- Drug: placebo（for probiotic）
Primary outcomes (3)
- measure
- Composition of Microorganisms in stool after probiotic intervention
- timeFrame
- 5 months
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Patients scheduled for chemotherapy after radical resection of colorectal cancer Exclusion Criteria: * Palliative resection of colorectal cancer * Antibiotic,probiotic or prebiotic usage within 1months * Other malignancy * History of other abdominal surgery * Coagulopathy or bleeding disorders * Pregnant or breast-feeding(for females) * Impaired liver or renal function
References
Publications (0)
Data not yet available
No reference posted for this study.