Clinical trial · Interventional
Remote Ischemia Precondition (RIPC) for Hepatic Protection in Patients Undergoing Hepatectomy
Remote Ischemia Precondition for Hepatic Protection in Patients Undergoing Hepatectomy: A Single-center Randomized Controlled Trial
NCT02168608CI-TRIAL-00014893unknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Remote ischemia precondition could protect the liver from ischemia reperfusion injury in patients undergoing hepatectomy.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Liver Neoplasms | Liver Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| None remote ischemia precondition | Other | — | UNRESOLVED |
| Remote ischemia precondition | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Remote ischemia precondition
- description
- patients in this arm accepted RIPC procedure after induction of anesthesia
- interventionNames
- Other: Remote ischemia precondition
- type
- EXPERIMENTAL
- label
- None remote ischemia precondition
- description
- patients in this arm didn't accept RIPC procedure after induction of anesthesia
- interventionNames
- Other: None remote ischemia precondition
Primary outcomes (1)
- measure
- survival rate
- timeFrame
- 30 days postoperatively
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: * No other main organ diseases, American society of Anesthesiologists (ASA) classification Ⅰ-Ⅱ grade * Selective hepatectomy, one time hepatic portal occlusion * Child-Pugh A Exclusion Criteria: * Peripheral vessels diseases * Not the same surgical procedure as expected * Administered anti-inflammatory drugs as glucocorticoid etc * Diagnosed of diabetes * History of liver surgery * History of hepatic interventional therapy, radiofrequency therapy,radiotherapy and chemotherapy * Refuse to join the research * Patients with psychopathy * Acute infection need antibiotic therapy * Hepatic artery or portal vein embolism
References
Publications (5)
- BACKGROUNDKin H, Zhao ZQ, Sun HY, Wang NP, Corvera JS, Halkos ME, Kerendi F, Guyton RA, Vinten-Johansen J. Postconditioning attenuates myocardial ischemia-reperfusion injury by inhibiting events in the early minutes of reperfusion. Cardiovasc Res. 2004 Apr 1;62(1):74-85. doi: 10.1016/j.cardiores.2004.01.006. PMID 15023554
- BACKGROUNDHuguet C, Addario-Chieco P, Gavelli A, Arrigo E, Harb J, Clement RR. Technique of hepatic vascular exclusion for extensive liver resection. Am J Surg. 1992 Jun;163(6):602-5. doi: 10.1016/0002-9610(92)90567-b. PMID 1595841
- BACKGROUNDDelva E, Camus Y, Nordlinger B, Hannoun L, Parc R, Deriaz H, Lienhart A, Huguet C. Vascular occlusions for liver resections. Operative management and tolerance to hepatic ischemia: 142 cases. Ann Surg. 1989 Feb;209(2):211-8. doi: 10.1097/00000658-198902000-00012. PMID 2916865
- BACKGROUNDClavien PA, Yadav S, Sindram D, Bentley RC. Protective effects of ischemic preconditioning for liver resection performed under inflow occlusion in humans. Ann Surg. 2000 Aug;232(2):155-62. doi: 10.1097/00000658-200008000-00001. PMID 10903590
- BACKGROUNDAzoulay D, Lucidi V, Andreani P, Maggi U, Sebagh M, Ichai P, Lemoine A, Adam R, Castaing D. Ischemic preconditioning for major liver resection under vascular exclusion of the liver preserving the caval flow: a randomized prospective study. J Am Coll Surg. 2006 Feb;202(2):203-11. doi: 10.1016/j.jamcollsurg.2005.10.021. PMID 16427543