Clinical trial · Observational
Olfactory Function Following Endoscopic Endonasal Skull Base Surgery
Olfactory Function Following Endoscopic Endonasal Skull Base Surgery: Clinical and Histological Outcomes
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Per PI request upon data analysis limitation discovery.
Summary
Brief summary (as posted)
The purpose of this study is to compare a subject's sense of smell before and after endoscopic endonasal surgery to remove a skull base abnormality (i.e. tumor, inflammatory process, fracture, defect, etc.) and use the information collected to validate approaches to surgery that will minimize side effects to the sense of smell function. Data will be collected using a smell identification test along with two questionnaires. In addition, demographic, medical history, treatment, outcome, and follow-up information will be collected.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Skull Base Pathology | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| endoscopic endonasal surgery with UPSIT | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- patients undergoing EEA requiring a nasoseptal flap
- description
- endoscopic endonasal surgery undergoing a nasoseptal flap for reconstruction monitored with UPSIT prior to surgery and at months 1, 3, 6, and 12 after surgery.
- interventionNames
- Procedure: endoscopic endonasal surgery with UPSIT
- label
- patients undergoing EEA NOT requiring a nasoseptal flap followed up with UPSIT
- description
- endoscopic endonasal surgery NOT undergoing a nasoseptal flap for reconstruction monitored with UPSIT prior to surgery and at months 1, 3, 6, and 12 after surgery.
- interventionNames
- Procedure: endoscopic endonasal surgery with UPSIT
Primary outcomes (1)
- measure
- Changes in UPSIT Score for the Two Groups Undergoing Endoscopic Endonasal Surgery With or Without Flap
- timeFrame
- up to 12 months post surgery
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients presenting with skull base pathologies requiring endonasal surgery at The Ohio State University Wexner Medical Center * 18 years or older * Able to consent for self * Negative serum pregnancy test for women of childbearing potential Exclusion Criteria: * Patient unable to return to clinic at specific follow-up times * Pregnant or nursing * Prisoners
References
Publications (0)
Data not yet available