Clinical trial · Observational
Changes Associated With H. Pylori and Gastric Carcinogenesis
Next-Generation Sequencing to Evaluate Transcriptomic Changes Associated With H. Pylori Infection and Gastric Cancer Carcinogenesis
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a research study for patients who currently have or previously had an H. pylori infection or who have gastric or esophageal cancer and who plan to undergo an endoscopy as part of their care. The purpose of this study is to find out how and why H. pylori infections can cause progression to gastric cancer and if it's possible for intervention prior to this progression.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Bacterial Infection Due to Helicobacter Pylori (H. Pylori) | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Endoscopy tissue collection | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Patient
- description
- Subjects for this study will be either H. pylori positive with an active infection, cleared of an H. pylori infection or be both H. pylori antibody positive and have a malignancy of the gastrointestinal tract, specifically gastric adenocarcinoma.
- interventionNames
- Procedure: Endoscopy tissue collection
- label
- Control
- description
- A small subset of patients without H. pylori infection will be enrolled as well (n=30) to serve as a control group.
- interventionNames
- Procedure: Endoscopy tissue collection
Primary outcomes (1)
- measure
- Identify genomic alterations associated with H. pylori infection
- timeFrame
- Within 3 years of tissue collection
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patient must be 18 years or older * Patient must have active or prior H. pylori infection, or have been treated for H.pylori infection in the past, as assessed by ELISA (not applicable for the subset of patient controls) or have gastric or esophageal cancer or have Barrett's Esophagus * Patients must be eligible for and are planning to undergo a routine upper endoscopy and tissue biopsy * Patients must sign informed consent Exclusion Criteria: * Prior history of upper GI bleed (within 3 months) * Bleeding disorder or coagulopathy * Recent stroke or myocardial infarction (within 3 months)
References
Publications (0)
Data not yet available