In Vitro Functional Modulation of Monocyte-derived Dendritic Cells of Patients With Cancer by Peptides

Inclusion Criteria:

1. Signature of the Informed Consent Form before the performing of any procedures related to the study;
2. Age ≥18 years;
3. Histologically confirmed metastatic malignant neoplasia;
4. Results of laboratorial exams in the first 6 weeks before the blood sample collection within the following values:

   * White blood cells ≥ 3.000/μL;
   * Platelet count ≥ 100,000/mm³;
   * Hemoglobin \> 10g/dL;
   * Serum aspartate aminotransaminase (AST), alanine aminotransferase (ALT) and alkaline phosphatase \< 2.5 x upper limit of normal (ULN);
   * Serum creatinine \< 1.5 x upper limit of normal (ULN);
5. Karnofsky performance status ≥ 70%.

Exclusion Criteria:

1. Presence of autoimmune disorders or conditions that require systemic treatment with immunosuppressant medications or systemic corticosteroids;
2. Received any systemic chemotherapy or radiotherapy within 15 days prior to the blood sample collection;
3. Received any immunotherapy within 4 weeks prior to the blood sample collection;
4. Known history of positive serology for HIV (human immunodeficiency virus).