Stereotactic Body Radiotherapy and Concurrent Cisplatin for Re-Irradiation of Unresectable, Recurrent Squamous Cell Carcinomas of Head and Neck

Inclusion Criteria:

* Recurrence of previously pathologically proven squamous cell carcinoma of the head and neck, including original primary sites in the paranasal sinuses, nasal cavity, nasopharynx, oropharynx, oral cavity, larynx, hypopharynx, salivary glands, and/or involvement of cervical lymph nodes
* Prior radiotherapy to doses ≥ 45 Gy to the area of recurrence, ≥ 6 months prior to enrollment
* Eastern Cooperative Oncology Group (ECOG) Performance Status 0 - 2
* Life expectancy \> 6 months
* Medically unfit for surgery or deemed surgically unresectable by head and neck (H\&N) surgeon within 60 days prior to enrollment, or patient refusal of surgery
* Normal organ and marrow function
* No prior evidence of Grade 3 or greater toxicity or neuropathy
* Medically fit to receive cisplatin

Exclusion Criteria:

* Positive urine pregnancy test and/or breastfeeding. Women of childbearing potential or sexually active males must be willing to use effective contraception throughout their participation in the treatment phase of the study.
* Evidence of distant metastases
* Tumor size \> 7 cm in one direction
* Tumor within 1 cm of the spinal cord
* Cardiac history: class III or greater congestive heart failure (CHF) or myocardial infarction (MI) within last 6 months
* Medical condition or social situation that at the discretion of the principal investigator (PI) would preclude them from completion of the trial