A Study of Subcutaneous Bevacizumab in Relapsed / Progressive Glioblastoma

Inclusion Criteria:

* Diagnosis: Participants with glioblastoma are eligible for this study. These will include

  * Those with a histologically proven diagnosis of glioblastoma who have developed new changes on MRI following primary treatment.
  * Those who received primary treatment for a histologically proven lower grade (2 or 3) glioma and who now progress with radiographic characteristics of transformed glioma.
* Disease status: Patients must have abnormal enhancement on contrast enhanced MRI of the brain. They must be patients for whom bevacizumab is indicated and appropriate, as drug will be charged to insurance.

  * Participants with newly detected enhancement are eligible, with bevacizumab treatment hoped to prevent symptoms.
  * Participants with stable enhancement / edema are eligible if they require corticosteroids to control symptoms, and it is thought bevacizumab treatment might allow lowering of the corticosteroid dose or improvement of symptoms.
* Performance status: Eastern Cooperative Oncology Group (ECOG) 0-3.
* Age: Greater than 18 years.
* Life expectancy: \> 3 months.
* Prior therapy:

  * Anti-VEGF treatments: 3 months must have elapsed between any prior anti-VEGF treatment (for example, given as a component of primary treatment) and study participation. These therapies include bevacizumab, cediranib, axitinib, sunitinib as well as other therapeutics targeting VEGF.
  * Other anti-cancer treatments: Treatments in this category include chemotherapy and targeted therapies not targeting VEGF. 14 days must have elapsed since discontinuation of prior chemotherapeutic treatments for glioma and study treatment.
* Radiation: Radiation is integral to the primary treatment of glioma. All participants on this study must have had prior radiation to the brain. Radiation must have been completed 14 days prior to first study treatment.
* Surgery: 14 days must have elapsed since prior major surgery.
* Organ function requirements:

  * Creatinine clearance of 50 or greater.
  * Absolute neutrophil count of 1500 or greater.
* Blood pressure requirements: Participants must have a baseline blood pressure of 160/90 or less. Participants requiring medicines to control blood pressure are eligible.
* Informed consent: All patients must sign a written informed consent.
* Urine pregnancy test: Women of childbearing age must have a negative urine pregnancy test.

Exclusion Criteria:

* People who progress with only nonenhancing tumor on MRI are ineligible. Patients must have some component of abnormal enhancement on contrast enhanced MRI of the brain. Combinations of nonenhancing and enhancing tumor are eligible.
* Pregnancy or breast-feeding: Pregnant or breast-feeding women will not be entered on this study.
* Renal insufficiency: Patients with a creatinine clearance of less than 50 are ineligible.
* Proteinuria: Patients with 2+ proteinuria/Moderate or more at baseline are ineligible.
* Comorbidities: Patients may not have any baseline comorbidities or laboratory abnormalities which would be of grade 3 or worse if graded as toxicities by CTCAE (excepting alopecia). An exception is also made for neurologic comorbidities (eg ataxia, aphasia) arising as a consequence of the brain tumor; symptoms severe enough to warrant medical treatment as is offered on this study are by definition grade 3.
* Patients who in the opinion of the investigator may not be able to comply with the safety monitoring requirements of the study.
* Illness or any other circumstances (as defined by the investigator), which would preclude safe performance of study procedures or compromise the ability of the patient to consent to study.