Clinical trial · Interventional
Enteral Feeding in Discharged Patients
Randomised Trial of Enteral Feeding in Patients Discharged From Hospital Following Surgical Resection of an Upper Gastrointestinal Malignancy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Failed to recruit full number of patients
Summary
Brief summary (as posted)
Patients due to undergo surgery for oesophageal and gastric malignancy are often malnourished. Up to 10% of patients preoperative weight may also be lost during the early postoperative period. Following discharge from hospital the mechanics of the surgery leads to a loss of gastric reservoir function, lack of appetite, altered intestinal motility and gastro-oesophageal reflux which usually results in reduced dietary intake and further weight loss. In patients who have undergone upper gastrointestinal resections there are no studies examining the benefit of nutritional supplementation following hospital discharge, however, studies in other groups of surgical patients have failed to show benefit. Despite patients who have undergone upper gastrointestinal surgery being 'at risk' nutritionally, there is no evidence demonstrating the value or not of nutritional supplementation following hospital discharge. Hypothesis: The postoperative under nutrition seen after upper gastrointestinal surgery will exacerbate the reduced quality of life and fatigue patients' already experience. The investigators hypothesise that improving patient's nutritional intake following hospital discharge will improve their quality of life and fatigue levels.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Nutritional Supplementation Via a Jejunostomy Post Discharge From Hospital | — | UNRESOLVED | — |
| Surgical Resection of an Upper Gastrointestinal Malignancy | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Jejunal feeding | Dietary Supplement | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Jejunal feeding
- description
- Nutritional supplementation via their jejunostomies for six weeks post hospital discharge, with continued assessment for a further 18 weeks.
- interventionNames
- Dietary Supplement: Jejunal feeding
- type
- NO_INTERVENTION
- label
- No jejunal feeding
- description
- No jejunal feeding of patients for six weeks following hospital discharge, with continued assessment for a further 18 weeks
Primary outcomes (1)
- measure
- Fatigue
- timeFrame
- 18 weeks
- description
- The primary outcome will therefore be fatigue as measured by the multidimensional fatigue inventory (MFI-20) score. The MFI-20 is divided into five scales: general fatigue, physical fatigue, reduced activity, reduced motivation and mental fatigue.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients able to give written informed consent, * Have had a feeding jejunostomy placed at surgery, * Competent (or their carer) to set up and use the jejunostomy feeding apparatus themselves. Exclusion Criteria: * Participating in another interventional trial, * Age \<18, * Pre-operative BMI \> 35, * Pre-operative BMI \<18, * Oral intake at hospital discharge of \> 90% of requirements, * It is felt that they or their carers would not to cope with home tube feeding Patients unable to give written informed consent.
References
Publications (0)
Data not yet available