Clinical trial · Observational
An Observational Study of Avastin (Bevacizumab) in Patients With Ovarian Cancer
Ascites Control Treating Ovarian Cancer With Bevacizumab: "ACT-OB"
NCT02151370CI-TRIAL-00014733completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This observational study will collect data about safety in female patients with advanced ovarian epithelial cancer with measurable residual disease after surger y. The treating physician has decided to treat the patients with Avastin (bevaci zumab) in combination with chemotherapy followed by Avastin monotherapy accordin g to the local label. Data will be collected for 72 weeks.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Ovarian Cancer | Malignant Ovarian Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (1)
- label
- Cohort
Primary outcomes (2)
- measure
- The proportion of patients who require paracenthesis during treatment with Avastin
- timeFrame
- 72 weeks
- measure
- The amount of ascitic fluid extracted during treatment with Avastin
- timeFrame
- 72 weeks
Secondary outcomes (3)
- measure
- Safety: Incidence of adverse events
- timeFrame
- 72 weeks
- measure
- To evaluate Eastern Cooperative Oncology Group (ECOG) performance status before and after start of therapy
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Female patients over 18 years of age * Histologically confirmed Advanced Epithelial Ovarian Cancer * Confirmed ascites prior to surgery * Residual disease after surgery * Patients are chemotherapy naïve or have received only one prior line of treatment for their disease * International Federation of Gynecology and Obstetrics (FIGO) stage IIIb or IV disease * Eastern Cooperative Oncology Group (ECOG) performance status \<=2 * Patients must meet treatment eligibility requirements according to treating physician and Summary of Product Characteristics (SmPC) criteria for Avastin plus chemotherapy. Exclusion Criteria: * Pregnancy or lactation * Low grade tumors, since this does not necessarily requires systemic treatment. Complete surgical resection * Uncontrollable hypertension * Unexplained bleeding * Known hypersensitivity to any components of bevacizumab * All contraindications specified in the respective Summary of Product Characteristics (SmPC) and/or local labelling of Avastin and the corresponding chemotherapy must be adhered to by the physician.
References
Publications (0)
Data not yet available
No reference posted for this study.