Clinical trial · Observational
Circulating Tumor Cells in Operative Blood
Circulating Tumor Cells Shed in Operative Blood During Pancreatectomy for Pancreatic Cancer is Responsible for Peritoneal Recurrence
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
It is hypothesized that circulating tumor cells (CTCs) from pancreatic adenocarcinoma are released into the peritoneal cavity through blood lost during the surgical resection of these tumors resulting in peritoneal recurrence despite appropriate surgical resection. Targeting the mechanisms responsible for CTC adhesion to the peritoneum may result in inhibition of implantation and growth, thus preventing this mode of pancreatic cancer recurrence postoperatively.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Carcinoma, Pancreatic Ductal | Carcinoma | ONTOLOGY_EXACT | 0.85 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Peripheral/Central Venous Blood Draw | Procedure | — | UNRESOLVED |
| Peritoneal Wash | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Pancreatic Cancer CTC
- description
- Peripheral/Central Venous Blood Draw Peritoneal Wash
- interventionNames
- Procedure: Peripheral/Central Venous Blood Draw
- Procedure: Peritoneal Wash
Primary outcomes (2)
- measure
- Percentage of patients with isolated circulating tumor cells
- timeFrame
- 2 days
- measure
- Percentage of patients with successful in vivo animal engraftment of isolated circulating tumor cells
- timeFrame
- 6 months
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 85 Years
Show eligibility criteria text
Inclusion Criteria: * Confirmed tissue diagnosis of pancreatic ductal adenocarcinoma * Scheduled to undergo pancreatectomy (open or minimally invasive) with curative intent * Aged 18-85 years * No race restrictions Exclusion Criteria: * Patients who have undergone preoperative therapy with either chemotherapy, radiation therapy, or both * Serum CA19-9 less than 200ng/ml * Patients with prior history of gastrointestinal malignancy
References
Publications (6)
- BACKGROUNDKatz MH, Wang H, Fleming JB, Sun CC, Hwang RF, Wolff RA, Varadhachary G, Abbruzzese JL, Crane CH, Krishnan S, Vauthey JN, Abdalla EK, Lee JE, Pisters PW, Evans DB. Long-term survival after multidisciplinary management of resected pancreatic adenocarcinoma. Ann Surg Oncol. 2009 Apr;16(4):836-47. doi: 10.1245/s10434-008-0295-2. Epub 2009 Feb 5. PMID 19194760
- BACKGROUNDSugiura T, Uesaka K, Mihara K, Sasaki K, Kanemoto H, Mizuno T, Okamura Y. Margin status, recurrence pattern, and prognosis after resection of pancreatic cancer. Surgery. 2013 Nov;154(5):1078-86. doi: 10.1016/j.surg.2013.04.015. Epub 2013 Aug 22. PMID 23973112
- BACKGROUNDKatz MH, Pisters PW, Evans DB, Sun CC, Lee JE, Fleming JB, Vauthey JN, Abdalla EK, Crane CH, Wolff RA, Varadhachary GR, Hwang RF. Borderline resectable pancreatic cancer: the importance of this emerging stage of disease. J Am Coll Surg. 2008 May;206(5):833-46; discussion 846-8. doi: 10.1016/j.jamcollsurg.2007.12.020. Epub 2008 Mar 17. PMID 18471707
- BACKGROUNDKuramoto M, Shimada S, Ikeshima S, Matsuo A, Kuhara H, Eto K, Baba H. A proposal of a practical and optimal prophylactic strategy for peritoneal recurrence. J Oncol. 2012;2012:340380. doi: 10.1155/2012/340380. Epub 2012 Feb 8. PMID 22481921
- BACKGROUNDKuramoto M, Shimada S, Ikeshima S, Matsuo A, Yagi Y, Matsuda M, Yonemura Y, Baba H. Extensive intraoperative peritoneal lavage as a standard prophylactic strategy for peritoneal recurrence in patients with gastric carcinoma. Ann Surg. 2009 Aug;250(2):242-6. doi: 10.1097/SLA.0b013e3181b0c80e. PMID 19638909
- BACKGROUNDCancer Facts & Figures 2013. Atlanta: American Cancer Society; 2013