Clinical trial · Interventional
Effectiveness Study of Resection of Primary Tumor in Stage IV Colorectal Cancer Patients
Palliative Resection of Asymptomatic Primary Tumor Following Effective Induction Chemotherapy in Colorectal Cancer Patients With Unresectable Distant Metastasis: a Multi-center, Prospective, Randomized Controlled Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
There is still no perfect treatment suggestion for patients with asymptomatic colorectal cancer with unresectable metastatic disease. Whether patients can benefit from palliative resection of primary tumor or not is still waiting for answer. The investigators hypothesis that asymptomatic metastatic colorectal cancer patients who respond to chemotherapy will benefit from primary tumor resection.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer Metastatic | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Surgical resection of primary tumor | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Surgical treatment group
- description
- Unresectable mCRC patients who respond to chemotherapy will receive surgical resection of primary tumor.
- interventionNames
- Procedure: Surgical resection of primary tumor
- type
- NO_INTERVENTION
- label
- Chemotherapy group
- description
- Unresectable mCRC patients who were respond to chemotherapy will continue with chemotherapy.
Primary outcomes (1)
- measure
- Overall survival
- timeFrame
- 3 years
Secondary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * 18 to 70 years old * both genders * ECOG:0-2 score * Pathological confirmed colon cancer or rectal cancer with at least 12 cm far away from anal verge * CT,MRI,or PET-CT confirmed metastasis * MDT confirmed unresectable metastasis lesion * No evidence of obstruction, bleeding, perforation * WBC≥4.0×109/L，Neu ≥2.0×109/L，PLT≥100×109/L * No contraindication for chemotherapy * No evidence of other malignant tumor * Expected survival time \> 6 months Exclusion Criteria: * mCRC patients who did not respond to first line chemotherapy * Require surgical intervention during the primary tumor-related symptoms * Obvious coagulopathy * Severe heart, liver, kidney damage or other serious uncontrolled medical illness or acute infection, cachexia * Severe organ damage after chemotherapy, surgery or unable to continue to systemic chemotherapy * Pregnant or lactating women or women of childbearing age who refuse to accept contraception. * Nearly three months participated in clinical trials of other persons. * Mental abnormalities
References
Publications (0)
Data not yet available