Clinical trial · Interventional
The Effect of Propofol Based Total Intravenous Anesthesia on Oxidative Stress and Nitric Oxide
The Effect of Propofol Based Total Intravenous Anesthesia on Oxidative Stress and Nitric Oxide in Patients Undergoing Laparoscopic Surgery
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Robot assisted laparoscopic radical prostatectomy(Robot-LRP) requires pneumoperitoneum and trendelenburg position which result in oxidative stress and inflammatory response. Propofol is well known to reduce those responses during anesthesia. Therefore, we try to figure out the efficacy of propofol to reduce oxidative stress, inflammatory response and increase the nitric oxide activity during robot-LRP compared to that of desflurane. To investigate the oxidative stress, malondialdehyde will be measured. As inflammatory markers, interleukin-1β, interleukin-6, tumor necrosis factor-α will be measured. Nitric oxide will be measured as well. Secondarily, kidney protection effect of propofol over desflurane will be compared.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Prostate Cancer | Malignant Prostate Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Desflurane | Drug | — | UNRESOLVED |
| propofol | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- desflurane
- description
- use desflurane as a primary anesthetics during anesthesia guided by bispectral index (BIS)
- interventionNames
- Drug: Desflurane
- type
- EXPERIMENTAL
- label
- propofol
- description
- propofol infusion with target-controlled infusion(TCI) device guided by BIS
- interventionNames
- Drug: propofol
Primary outcomes (1)
- measure
- changes of serum malondialdehyde, Interleukin-1β, interleukin-6, tumor necrotic factor-α, nitric oxide during operation
- timeFrame
- 100 min after pneumoperitoneum, 10 min after decompression
Eligibility
Eligibility (as posted)
- Sex
- Male
- Minimum age
- 20 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: * patients undergoing robot-assisted laparoscopic radical prostatectomy under general anesthesia Exclusion Criteria: * chronic renal failure ( estimated glomerular filtration rate \<60 mL/min/1.73m2) * allergy to propofol, nuts * on diuretics, vitamin C or vitamin E within 5 days before surgery * Body mass index \> 30 kg/m2 * older than 70 years * who cannot read the patient consent form
References
Publications (0)
Data not yet available