Clinical trial · Observational
Assessment of Hepatitis B Virus Intra-host Population and Host-specific Immune Marker Diversity
Assessment of Hepatitis B Virus Intra-host Population and Host-specific Immune Marker Diversity With Next-generation Sequencing: From Chronic Infection to End-stage Liver Disease and Liver Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
In this project proposal, the investigators will investigate the genetic alterations of Hepatitis B Virus (HBV) strains circulating in Belgian patients who developed end stage liver disease. Additionally, the investigators will compare and link these data sets with three genetic factors involved in immune system response.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Carcinoma, Hepatocellular | Hepatocellular Carcinoma | ONTOLOGY_EXACT | 0.98 |
| End Stage Liver Disease | — | UNRESOLVED | — |
| Hepatitis B | — | UNRESOLVED | — |
| Hepatitis B, Chronic | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (2)
- label
- Chronic Hepatitis B
- description
- Diagnosis of Hepatitis B related liver disease in a pre-advanced stage
- label
- End stage liver disease
- description
- Diagnosis of advanced liver disease related to Hepatitis B
Primary outcomes (1)
- measure
- genetic variants of Hepatitis B
- timeFrame
- 6 months
- description
- Virus variants will be identified by amino acid or nucleotide variations (insertions or deletions) in different Open Readind Frames (ORFs) of the HBV genome by using next-generation sequencing. Comparison of virus variants within one patient Comparison of virus variants between patients with end stage liver disease and patients with a chronic Hepatitis B infection. Determination of the viral load by quantitative Polymerase Chain Reaction (PCR).
Secondary outcomes (1)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: Study group: * Clinical diagnosis of advanced liver disease related to chronic Hepatitis B infection (cirrhosis, hepatocellular carcinoma,..) * Availability of serum samples Control group: * Clinical diagnosis of liver disease related to chronic Hepatitis B infection in a pre-advanced stage * Matched demographic and geographic characteristics to study group * Availability of serum samples Exclusion Criteria: * Liver disease caused by other hepato-tropic viruses * Patients with auto-immune diseases
References
Publications (0)
Data not yet available