Tangerine or Red Tomato Juice in Treating Patients With Prostate Cancer Undergoing Surgery

Inclusion Criteria:

* Have biopsy proven carcinoma of the prostate
* Have chosen a radical prostatectomy for treatment of their disease after the medical team has presented all possible treatment options
* Not be receiving neoadjuvant hormonal or chemotherapy (other clinical trials)
* Have an Eastern Cooperative Oncology Group (ECOG) performance status of 0-1
* Not currently be taking tomato carotenoid dietary supplements or "alternative" products (e.g., lycopene supplements, Lyc-O-Mato, saw palmetto); vitamin A and beta-carotene supplements are allowed
* Not be allergic to tomatoes or tomato products
* Have plasma total cholesterol \< 200 mg/dL
* Plasma triglycerides \< 200 mg/dL
* Have blood urea nitrogen and serum creatinine (BUN/Cr) without clinically significant abnormalities after review by the study physicians
* Liver enzymes without clinically significant abnormalities after review by the study physicians
* Complete blood count (CBC) without clinically significant abnormalities after review by the study physicians
* Prothrombin time (PT) without clinically significant abnormalities after review by the study physicians
* Partial thromboplastin time (PTT) without clinically significant abnormalities after review by the study physicians
* International normalized ratio (INR) without clinically significant abnormalities after review by the study physicians
* Voluntarily agree to participate and sign an informed consent document
* Agree to have prostate biopsy blocks provided to the study for evaluation
* Agree to consume a standardized vitamin and mineral supplement and avoid other nutrition, dietary, or alternative medications/supplements for the duration of the study
* Agree to follow a low lycopene and phytoene diet

Exclusion Criteria:

* Have an active malignancy other than prostate cancer that requires therapy
* Have a prostate biopsy with less than 5% cancer involvement
* Have a history of traumatic or surgical castration
* Have plasma total cholesterol \> 200 mg/dL
* Have plasma triglycerides \> 200 mg/dL
* Have a history of uncontrolled pituitary hormone diseases that currently require varying doses of supplemental hormonal administration (thyroid hormones, adrenocorticotropic hormone \[ACTH\], growth hormone) or other endocrine disorders requiring varying doses of hormone administration with the exception of diabetes and osteoporosis
* Are planning to start certain medications after the trial enrollment; no new finasteride (Proscar) or other hormonal agents for chemoprevention/treatment of benign prostate hyperplasia (BPH); utilizing new prescription medications for urinary outlet obstructive symptoms will result in discontinuing participation in this study; the use of new non-prescription substances to improve urinary tract symptoms will also result in discontinuing participation (i.e. saw palmetto, other herbal, alternative products); men who are currently taking finasteride or medications (meds) for urinary outlet obstructive symptoms may enroll in the study as long as there is no plan to change the dose in the weeks prior to surgery
* Have a known allergy to tomatoes or have never consumed tomatoes
* Have active metabolic or digestive illnesses such as malabsorptive disorders (Crohn's, Celiac disease, irritable bowel syndrome \[IBS\]), renal insufficiency, hepatic insufficiency, cachexia, or short bowel syndrome
* Have significant loss of gastrointestinal organs, except for appendix, due to surgery
* Have altered immunity such as autoimmune disorders, clinically significant anemia, hemophilia, and blood dyscrasias