Clinical trial · Observational
Monocyte Phenotypic and Functional Differences
A Canine/ Human Translational Model of Phenotypic and Functional Differences Between Monocytes in Patients With and Without Sarcoma
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to identify phenotypic (cell surface receptor expression) and functional differences in monocyte populations in humans with osteosarcoma as compared to published historical data on normal human monocyte values. The biologic similarity between canine and human osteosarcoma makes it a disease model that holds promise for translational research possibilities. The phenotypic and functional differences the investigators expect to find in canine and human monocytes between normal and osteosarcoma subjects in this pilot work will allow us to launch a program of investigations to further their understanding as to what characteristics are associated with improved survival in canine and human osteosarcoma. Such data will represent the foundation upon which the investigators can plan future investigations designed to exploit the potential anti-tumor capabilities of monocytes and macrophages in canine and human osteosarcoma.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Osteosarcoma | Osteosarcoma | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Blood draw | Biological | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Patients newly diagnosed with osteosarcoma
- description
- Blood draw
- interventionNames
- Biological: Blood draw
Primary outcomes (1)
- measure
- Variations in the intensity of cell surface receptor expression
- timeFrame
- 1 day
- description
- We will characterize the phenotypic differences demonstrated by variations in cell surface receptor expression, such as CCR2, CCR7 and CD32, between normal monocytes and monocytes in osteosarcoma patients.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 6 Years
Show eligibility criteria text
Inclusion Criteria: * Patients presenting for evaluation of osteosarcoma of the appendicular skeleton * Patient is 6years or older at time of visit * Patients do not need to be eligible for surgery * Patients may have known infection related to osteosarcoma and its treatment (ex. surgical wound infection) * Patients who would normally have a blood draw as part of their standard care Exclusion Criteria: * Patients younger than 10 years of age * Patients who are unwilling/unable to undergo blood draw * Patients with known infection unrelated to osteosarcoma or its treatment * Patients with known systemic immune-mediated disease including but not limited to lymphoma, AIDS/HIV, Lupus, etc.
References
Publications (0)
Data not yet available